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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not specified
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N-diethyl-2-propynylamine
EC Number:
223-804-5
EC Name:
N,N-diethyl-2-propynylamine
Cas Number:
4079-68-9
Molecular formula:
C7H13N
IUPAC Name:
diethyl(prop-2-yn-1-yl)amine
Specific details on test material used for the study:
Name of the test substance used in the study report: Golpanol DEP = 1-Diethylaminopropin

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
- Mean body weight: males: 193 g; females: 163 g
- The animals were offered a standardized animal laboratory diet (Altromin R 1324, Altromin GmbH, Lage, Germany)

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
- Emulsion in 0.5% aqueous CMC preparation with 2 - 3 drops Cremophor EL
- Test concentrations: 3.16, 4.64, 5.62, 6.81, 12.1, 14.7, 17.8 and 21.5% (V/V)
Doses:
316, 464, 462, 681, 1210, 1470, 1780 and 2150 µL/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 472 mg/kg bw
Remarks on result:
other: original value: 590 µL/kg
Mortality:
- At doses 316 and 464 µL/kg: no deaths after 14 days
- At dose 562 µL/kg: 4/10 deaths after 14 days
- At dose 681 µL/kg: 8/10 deaths after 14 days
- At all higher dose levels: 10/10 deaths after 14 days
Clinical signs:
other: Dyspnea, apathy, abdominal position, staggering, partly atony, twitching, trembling, partly biting convulsions, partly clonic convulsions, cyanosis, partly lacrimation, poor general state.
Gross pathology:
- 2150 µL/kg: limited bloating and pneumonic areas in the lungs
- 1210-1780 µL/kg: Heart: acute dilatation, specifically at the richt side; acute congestive hyperemia
- 681 µL/kg: Pneumonic areas in one animal
- 562 µL/kg: heart: acute dilatation, specifically of the atrium; stomach: congestive, thin content.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria