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Diss Factsheets
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EC number: 241-300-3 | CAS number: 17265-14-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Skin sensitisation in guinea pigs via intradermal injection of the test substnace for induction (seven doses) and challenge.
- GLP compliance:
- not specified
- Remarks:
- pre-GLP
- Type of study:
- intracutaneous test
- Justification for non-LLNA method:
- The LLNA was not established at that time.
Test material
- Reference substance name:
- Sebacic acid
- EC Number:
- 203-845-5
- EC Name:
- Sebacic acid
- Cas Number:
- 111-20-6
- Molecular formula:
- C10H18O4
- IUPAC Name:
- sebacic acid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Sweetwater Farms
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal
- Vehicle:
- peanut oil
- Concentration / amount:
- 0.1%
- Day(s)/duration:
- 15 days
- Adequacy of induction:
- other: 7 injections of the test substance evenly distributed over 15 days
Challenge
- No.:
- #1
- Route:
- intradermal
- Vehicle:
- peanut oil
- Concentration / amount:
- 0.1 %
- Day(s)/duration:
- 48 h
- Adequacy of challenge:
- other: injection of the test substance
- No. of animals per dose:
- 20
- Details on study design:
- Twenty male albino guinea pigs were used to test the sensitizing potential of the materials. The sensitization test was started on a Monday when the guinea pigs were weighed and closely clipped on the scapular areas. The material (0.05 mL of a 0.1% dilution in peanut oil) was injected intradermally into the upper right scapular area of each pig. A similar injection of peanut oil alone into the upper left scapular area served as a control site. Readings were made 24 and 48 hours later. Doses of 0.1 mL of the same dilutions (freshly prepared) were injected into the clipped dorsal lumbo-sacral areas of the guinea pigs on the following Wednesday, Friday, Monday, etc., until seven doses were administered. Care was taken to insure that the repeated doses were not injected into the same site. The guinea pigs were rested for three weeks (incubation period), weighed and given a challenge dose of 0.05 mL of the 0.1% dilution of the test material into the lower right scapular area. A control injection of the vehicle alone was also administered into the lower left scapular area at this time. The reactions were read after 24 and 48 hours.
Results and discussion
In vivo (non-LLNA)
Results
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.1 %
- No. with + reactions:
- 3
- Total no. in group:
- 20
- Remarks on result:
- other: No. of sensitized animals were not given in the report. Highest number of sensitized animals in the corresponding category was chosen.
Any other information on results incl. tables
Sebacic acid caused a mild sensitization response (final grades per animal: 26 -99) and was categorized as a substance with "slight" sensitization potential. According to the applied scoring system, this refers to 1 - 3 animals out of 20 with mild reactions (final grade per animal > 26, according to the corresponding grading system).
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
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