Benzenesulfonic acid, mono- and dialkylation products with C16-20 (even numbered, branched and linear) olefins, barium salts, barium carbonate, overbased, including distillates (petroleum), hydrotreated, solvent-refined, solvent-dewaxed, or catalytic dewaxed, light or heavy paraffinic C15-C50

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not reported

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

They study was performed in accordance with generally accepted scientific principles. The study was presented as a short abstract, but appears sufficient to consider reliable.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1966

Report date:

1966

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The acute dermal toxicity of the test material was determined in a study performed on the closely clipped, intact skin of 3 male and 3 female New Zealand White rabbits. Animals were exposed to the undiluted test material under an occlusive dressing for 24 hours. The test material was applied at dose levels increasing at increments of 0.2 fractional log intervals; 1000, 1580, 2510, 3980, 6310 mg/kg bw.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzenesulfonic acid, mono- and dialkylation products with C16-20 (even numbered, branched and linear) olefins, barium salts, barium carbonate, overbased, including distillates (petroleum), hydrotreated, solvent-refined, solvent-dewaxed, or catalytic dewaxed, light or heavy paraffinic C15-C50

Molecular formula:

Not possible, UVCB

IUPAC Name:

Benzenesulfonic acid, mono- and dialkylation products with C16-20 (even numbered, branched and linear) olefins, barium salts, barium carbonate, overbased, including distillates (petroleum), hydrotreated, solvent-refined, solvent-dewaxed, or catalytic dewaxed, light or heavy paraffinic C15-C50

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Details on test animals or test system and environmental conditions:

- Housing: Animals were caged individually during exposure.

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Preparation of exposure area: The skin of each animal was closely clipped and left intact.
- Type of wrap if used: The treated area was covered with plastic strips.
- Restraints: The animals were placed in wooden stocks for the duration of the exposure period.

Duration of exposure:

24 hours

Doses:

1000, 1580, 2510, 3980, 6310 mg/kg bw

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 1 580 - < 3 980 mg/kg bw

Based on:

test mat.

Clinical signs:

lethargy (hypoactivity)

observations of tremors

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Under the conditions of the test, the LD50 was determined to be >1580<3980 mg/kg bw.

Executive summary:

The acute dermal toxicity of the test material was determined in a study not performed according to any specified guideline. The test material was applied, undiluted, to the closely clipped, intact skin of New Zealand White rabbits. Animals were exposed to the test material under an occlusive dressing for 24 hours. The test material was applied at dose levels increasing at increments of 0.2 fractional log intervals; 1000, 1580, 2510, 3980, 6310 mg/kg bw. One rabbit was used per dosing level. Animals were caged individually during exposure and observed for signs of toxicity. The LD50 was determined to be > 1580<3980 mg/kg bw.