Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-410-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 130 mg/m³
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: Deutsche Forschungsgemeinschaft (DFG) Maximale Arbeitsplatzkonzentration (MAK) value
- Overall assessment factor (AF):
- 1
- Modified dose descriptor starting point:
- other: MAK value
- Value:
- 130 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The MAK value was derived based on all the appropriate assessment factors. No further assessment factors applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
The DNG (2019) MAK value of 130 mg/m3 was recommended to protect against acute neurotoxic effects and mucus membrane irritation. A 4-hour resting NOAEC of 200 mg/m3 was identified based on these effects. Exposure at 100 mg/m3 is not expected to result in acidosis. It is appropriate to use the MAK value as the worker inhalation systemic long-term DNEL.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 26 mg/m³
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: DFG MAK value
- Overall assessment factor (AF):
- 5
- Dose descriptor starting point:
- other: MAK value
- Value:
- 130 mg/m³
- Modified dose descriptor starting point:
- other: modifed MAK value
- Value:
- 26 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The MAK value was derived based on all the appropriate assessment factors. Since the MAK value already takes into account some human variability, a reduced assessment factor of 5 is applied for intraspecies differences for the general population.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 26 400 mg/m³
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: ECHA RAC DNEL (ECHA/RAC/RES-O-0000006324-78-01/F)
- Overall assessment factor (AF):
- 1
- Dose descriptor starting point:
- other: ECHA RAC DNEL (ECHA/RAC/RES-O-0000006324-78-01/F)
- Value:
- 88 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
The ECHA Committee for Risk Assessment (RAC) issued an opinion on methanol (ECHA/RAC/RESO-0000006324-78-01/F; ECHA, 2015). In this opinion, a DNEL for short-term oral exposures was derived based on the minimal oral methanol dose related to severe ocular toxicity; LOAEL = 0.26 g/kg bw. An assessment factor of 3 was applied to this LOAEL to derive a oral short-term systemic DNEL of 0.088 g/kg bw (88 mg/kg bw).
The oral LOAEL is used as the dose descriptor starting point for derivation of the inhalation short-term DNEL:
The REACH standard daily inhalation volume for humans is 20 m³/person/day.
To convert this daily volume to a 15 minute volume: 20 m³/person/day ÷ (24 hr/d x 4-15 min periods/hr) = 0.2 m³/person/15 minutes.
The DNEL of 88 mg/kg bw is equivalent to 5280 mg/person (assuming a body weight of 60 kg).
It follows therefore, that to acheive a dose of 5280 mg/person during 15 minutes of exposure, the inhaled
concentration would need to be: 5280 mg/person ÷ 0.2 m³/person/15 minutes = 26400 mg/m³.
- AF for dose response relationship:
- 1
- Justification:
- The basis of the DNEL is a LOAEL, but the RAC DNEL already includes an assessment factor of 3.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- LOAEL is from human data
- AF for other interspecies differences:
- 1
- Justification:
- LOAEL is from human data
- AF for intraspecies differences:
- 1
- Justification:
- RAC (ECHA/RAC/RES-O-0000006324-78-01/F) did not use an assessment factor for intraspecies differences.
- AF for the quality of the whole database:
- 1
- Justification:
- Default value.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: based on information in methanol disseminated dossier
- Overall assessment factor (AF):
- 5
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
The DNG (2019) MAK value of 130 mg/m3 was recommended to protect against acute neurotoxic effects and mucus membrane irritation. A 4-hour resting NOAEC of 200 mg/m3 was identified based on these effects. Exposure at 100 mg/m3 is not expected to result in acidosis. It is appropriate to use the MAK value as the basis for deriving the general population inhalation systemic long-term DNEL.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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