Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-313-3 | CAS number: 461-72-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
- Remarks:
- The study was not designed to test the acute toxic effects of Hydantoin. The study intention was to investigate if pre-treatment with hydantoin is effective with regard to attenuation of DDT-induced neurotoxicity.
Data source
Reference
- Reference Type:
- publication
- Title:
- Pharmacological modification of DDT-induced tremor and hyperthermia in rats: distributional factors.
- Author:
- Herr et al.
- Year:
- 1 986
- Bibliographic source:
- Psychopharmacology (Berl). 1986;89(3):278-83.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was not designed to test the acute toxic effects of Hydantoin. The study intention was to investigate if pre-treatment with hydantoin is effective with regard to attenuation of DDT-induced neurotoxicity.
- Test type:
- other: alternative test design not aiming to investigate the acute toxic effects of hydantoin
Test material
- Reference substance name:
- Hydantoin
- EC Number:
- 207-313-3
- EC Name:
- Hydantoin
- Cas Number:
- 461-72-3
- Molecular formula:
- C3H4N2O2
- IUPAC Name:
- hydantoin
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- Sigma Chemical Co., St. Louis, MO
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
- Age at study initiation: 9-13 weeks
- Housing: plastic home cages with corncob bedding in groups of four
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21+/-2 ° C
- Humidity (%): 50+/-10%
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 75 mg/kg
- No. of animals per sex per dose:
- 4
- Details on study design:
- Two pretreatment groups received hydantoin (75 mg/kg, PO; Sigma Chemical Co., St. Louis, MO) suspended in polyoxyethylene sorbitan mono-oleate (Tween 80; 2drops/10ml distilled water; Sigma Chemical Co., St. Louis, MO)
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: NOEL
- Effect level:
- 75 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable because of methodological limitations
Any other information on results incl. tables
Pharmacological pretreatment had minimal effects on animals not exposed to DDT.
Pretreatment with Hydantoin significantly decreased DDT-induced tremor.
Pharmacological pretreatment also altered DDT-induced hyperthermia. Pretreatment of animals with hydantoin (t=4.86; df=13; P<0.0001) significantly attenuated DDT-induced hyperthermia.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In a study investigating Hydantoin-induced attenuation of DDT-induced neurotoxicity, male rats were pre-treated with 75 mg/kg Hydantoin. US EPA cited an NOEL/LOEL of 75 mg/kg bw. However, as Hydantoin dosing was followed by DDT, a clear NOEL can not be concluded from this study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.