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Diss Factsheets
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EC number: 282-544-0 | CAS number: 84254-97-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006-01-30 to 2006-02-28
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
- Reference Type:
- other: Expert report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: SPL Standard Test Method 595.12
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- The study was conducted in a facility operating to Good Laboratory Practice within the UK national GLP monitoring programme, but the study report had not been audited by the QA Unit. No formal claim of GLP compliance was made for the study.
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 1'-(phenylmethyl)-[1,4'-bipiperidine]-4'-carbonitrile
- EC Number:
- 282-544-0
- EC Name:
- 1'-(phenylmethyl)-[1,4'-bipiperidine]-4'-carbonitrile
- Cas Number:
- 84254-97-7
- Molecular formula:
- C18H25N3
- IUPAC Name:
- 1'-benzyl-[1,4'-bipiperidine]-4'-carbonitrile
- Details on test material:
- - Name of test material (as cited in study report): T745
- Substance type: No data
- Physical state: No data
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot/batch No.: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data
- Other: No data
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: No data
- Expiration date of the lot/batch: No data
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: No data
- Stability under test conditions: No data
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: No data
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA/Ca
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Initial Body Weight: 18 - 20 grams
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 2.5%, 5%, 10% w/w
- No. of animals per dose:
- 4
- Details on study design:
- Following a preliminary sighting test, at which there were no signs of systemic toxicity at a concentration of 10% w/w, three groups, each of four animals, were treated with 50 uL (25 uL per ear) of the test material as a solution in acetone/olive oil 4:1 at concentrations of 2.5, 5, and 10% w/w. A further group of four animals was treated with acetone/olive oil 4:1 alone. Animals received doses daily for three days. Clinical observations for signs of toxicity, mortality and body weight were made pre-dose and 1-hour post dose on days one through three. Daily observations were made for the following three days.
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
- other: 2,4-dinitrobenzenesulfonic acid, sodium salt; see below for other information on material and methods
- Statistics:
- No data
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 1.62
- Test group / Remarks:
- 2.5% w/w
- Remarks on result:
- other: Negative
- Parameter:
- SI
- Value:
- 1.35
- Test group / Remarks:
- 5% w/w
- Remarks on result:
- other: Negative
- Parameter:
- SI
- Value:
- 2.94
- Test group / Remarks:
- 10% w/w
- Remarks on result:
- other: Negative
- Parameter:
- other: disintegrations per minute (DPM)
- Value:
- 13 082.14
- Test group / Remarks:
- 2.5% w/w
- Parameter:
- other: disintegrations per minute (DPM)
- Value:
- 10 905.4
- Test group / Remarks:
- 5% w/w
- Parameter:
- other: disintegrations per minute (DPM)
- Value:
- 23 710.52
- Test group / Remarks:
- 10% w/w
- Parameter:
- other: disintegrations per minute (DPM)
- Value:
- 8 057.44
- Test group / Remarks:
- Vehicle
Any other information on results incl. tables
The test material was considered a non-sensitiser (SI<3) under the conditions of the test. There were no signs of toxicity or mortality at any time.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (indication of skin sensitising potential) based on GHS criteria
- Conclusions:
- The test material was considered to be a non-sensitiser under the conditions of the test. No mortality or signs of systemic toxicity were observed during the test.
T000745 is to be classified as a Skin Sensitizer 1B based on a Janssen expert statement following this study conclusion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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