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EC number: 268-974-1 | CAS number: 68155-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- From September 06, 1976 to September 02, 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: test guideline for testing the degree of accumulation of chemical substances in the fish body
- GLP compliance:
- no
- Test organisms (species):
- Cyprinus sp.
- Details on test organisms:
- TEST ORGANISM
- Common name: Jcarp.
- Average body length: ca 10 cm
- Average weight: ca 28 g
- Surface sterilization: 24 hours medical bathing in10 ppm chlorotetracyclin hydrochloride acid solution under standard conditions.
- Acclimation: 14 days at 25 °C.
- Route of exposure:
- aqueous
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 56 d
- Test temperature:
- 25.0 ± 2 °C
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 l glass vessel.
- Water flow: 582 l/day
PREPARATION OF FISH SAMPLE
Fish body weight and length were measured. Tissues were cutted into small pieces and suspended in 50 ml of 0.5 CH3CO2Na -HCl buffer (pH 2.8) and homogenized for 10 minutes (50 ml of water; 300 mg of proctase); pH adjustments were performed.
Residues were suspended in acetone (containing 30 water 50 ml). In order to filtrate, the residues udergo evapouration to solid state; successive passages were addition of methylalcohol (100 ml) and centrifugatin (8000 r.p.m. 5 min), 2 times.
At the end of this phase, residues were separated.
The test sample was dissolved in methylalcohol, treatment with water and ammonia and centrifuged (3000 r.p.m. 10 min).
RANGE-FINDING / PRELIMINARY STUDY
- Common name: Japanese Killifish.
- Fish weight: 0.2 g
- Test temperature: 25.0 ± 2 °C
- Results: 48 hrs TLm: 440 ppm
- Concentration setting: 400 ppm x 1/100 of 1/1000 where chosen. - Nominal and measured concentrations:
- 4 (concentration level 1) and 0.4 ppm (concentration level 2)
- Remarks on result:
- other: not determined
- Details on results:
- The converted concentrion of the substance resulted to be 1.06 ppm at the concentration of 4 ppm and 0.106 ppm at the concentration of 0.4 ppm.
Due to the low accumulation rate, the substance content was in traces or non-detectable. - Conclusions:
- The substance content was in traces or non-detectable.
- Executive summary:
The bioaccumulative potential of test item was assessed in carp. The test item concentration was measured in water and in fish tissues, by HPLC method. Based on the TLm value determined in preliminary test, two concentration levels were chosen: 4.0 (concentration level 1) and 0.4 ppm (concentration level 2).
The converted concentrion of the substance resulted to be 1.06 ppm at the concentration of 4 ppm and 0.106 ppm at the concentration of 0.4 ppm. Due to the low accumulation rate, the substance content was in traces or non-detectable.
Reference
Accumulation rate
Concentration level | 2 w | 4 w | 6 w | 8 w |
At 4.0 ppm | < 5.0 | < 5.0 | < 5.0 | < 5.0 |
At 0.4 ppm | < 50 | < 50 | < 50 | < 50 |
Traces or not detectable
Actual measured concentration level
Conc. level | 2 w | 4 w | 6 w | 8 w |
At 4.0 ppm | 4.36 | 3.93 | 3.80 | 3.90 |
At 0.4 ppm |
0.440 |
0.402 |
0.391 |
0.394 |
Description of key information
No bioaccumulation potential expected.
Key value for chemical safety assessment
Additional information
The substance is expected to possess a low potential for bioaccumulation, based on the screening evaluation taken into account the experimental log Pow.
In addition, the bioaccumulative potential of test item was assessed in carp. The test item concentration was measured in water and in fish tissues, by HPLC method. Based on the TLm value determined in preliminary test, two concentration levels were chosen: 4.0 (concentration level 1) and 0.4 ppm (concentration level 2).
The converted concentrion of the substance resulted to be 1.06 ppm at the concentration of 4 ppm and 0.106 ppm at the concentration of 0.4 ppm. Due to the low accumulation rate, the substance content was in traces or non-detectable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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