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EC number: 248-329-0 | CAS number: 27214-38-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 - 21 April 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Use of THF as test material carrier
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- Version 13 April 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The Department of Health of the Government of the United Kingdom, London, United Kingdom
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: water control, solvent control, 1 mg/L (nominal)
- Sampling method: At the start of the test the excess test solutions were sampled and at the end of the test one replicate of the dilution water control, solvent control and each test concentration was sampled. 5 ml of each sample was collected into 20 ml glass vials containing 5 ml of LCMS grade methanol and an aliquot transferred to autosampler vial. - Vehicle:
- yes
- Remarks:
- Tetrahydrofuran (THF)
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The test item was ground using a pestle and mortar prior to weighing. A primary stock concentrate of the test item, with a nominal concentration of 10 g/L, was prepared by adding a nominal 0.1 g of test item to 10 mL of tetrahydrofuran (THF). The resultant stock was observed to be clear and colourless and was used to prepare the 1 mg/L test solution. This was achieved by the direct addition of the appropriate amount of concentrate to dilution water via a microliter syringe into a stirring solution in a volumetric flask. The solvent control was prepared in the same way using solvent only.
- Controls: water control, solvent control
- Chemical name of vehicle: tetrahydrofuran (THF)
- Concentration of vehicle in test medium: 0.1 mL/L - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: freshwater flea
- Source: in-house cultures
- Age of parental stock: 14 ± 1 days - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 211.7 CaCO3 mg/L
- Test temperature:
- T (0h) = 20.9°C
T (24h) = 19.7-21.0°C
T (48h) = 19.7-20.7°C - pH:
- Control: 7.67-7.79
Solvent Control: 7.82-7.92
0.69 mg/L: 7.88-7.92 - Dissolved oxygen:
- Control: 9.00-9.04 mg O2/L
Solvent Control: 8.98-9.03 mg O2/L
0.69 mg/L: 8.86-8.98 mg O2/L - Conductivity:
- 615 μS/cm
- Nominal and measured concentrations:
- nominal (0h): water control, solvent control, 1 mg/L
measured (0h): < 0.08, < 0.08, 1.1 mg/L
nominal (48h): water control, solvent control, 1 mg/L
measured (48h): < 0.05, < 0.05, 0.28 mg/L
Mean measured concentration: 0.69 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beakers 250 mL
- Type: closed; covered with loose fitting glass lids
- Fill volume: 200 mL (approx. depth of 60 mm)
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Preparation of dilution water: according to Elendt B P and Bias W R (1990). Trace Nutrient Deficiency in Daphnia magna Cultured in Standard Medium for Toxicity Testing. Effects of the Optimisation of Culture Conditions on Life History Parameters of D. magna. Water Research, 24, 1157-1167.
- Total organic carbon: 0.9 mg/L
- Particulate matter: <3 mg/L
- Sum of metals: < 680 µg/L
- Pesticides: <0.01 μg/L
- Alkalinity: 39.8 CaCO3 mg/L
- Conductivity: 615 μS/cm
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light: 8 hours dark, with 20-minute dusk and dawn transition periods
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : immobility; any other adverse reactions to exposure
VEHICLE CONTROL PERFORMED: yes
RANGE-FINDING STUDY
- Results used to determine the conditions for the definitive study: a 1 mg/L test concentration was selected based on a non-GLP range finding study - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.69 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: none observed
- Validity criteria fulfilled:
- yes
- Remarks:
- see Table 2 at "Any other information on results incl. tables"
Reference
Table 1: Daphnia magna response
Time (hour) |
Mean measured concentration of [tradename] (Glycerol Monomyristate) (mg/L) |
Number immobilised per replicate |
Total number tested |
Total number immobilised |
Percentage immobilised |
|||
|
|
A |
B |
C |
D |
|
|
|
24 |
Control |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
Solvent control |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
|
0.69 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
|
48 |
Control |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
Solvent control |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
|
0.69 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
Table 2: Validity criteria for OECD 202.
Criterion from the guideline |
Outcome |
Validity criterion fulfilled |
In the control, including the control containing the solubilising agent, not more than 10% of the daphnids should have been immobilized. |
0% |
yes |
The dissolved oxygen concentration at the end of the test should be ≥ 3 mg/L in control and test vessels. |
>8 mg/L |
yes |
Description of key information
Aquatic invertebrates: EC50 (48 h) > 0.69 mg/L (measured, arithm. mean)
Key value for chemical safety assessment
Additional information
The acute toxicity of the source substance Glycerol monomyristate (CAS 27214-38-6) to aquatic invertebrateswas tested according to OECD 202 under GLP conditions. Daphnia magna were exposed for 48 hours to a nominal test substance concentration of 1 mg/L in a limit test. The test concentration was prepared using tetrahydrofuran (THF) as vehicle. The concentration of vehicle in test medium was 0.1 mL/L. The test substance concentration was analytically verified by HPLC at test start and after 48 hours. The mean measured concentration was 69% of nominal. Immobilisation of Daphnis was not observed. The determined EC50 (48 h) was > 0.69 mg/L (measured, arithm. mean) based on mobility.
Based on the results of the available short-term toxicity testacute toxic effects of Glycerol monomyristate (CAS 27214-38-6) on aquatic invertebrates are not expected up to the limit of water solubility.
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