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EC number: 604-144-0 | CAS number: 139525-77-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- No analytical determination was performed
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- yes
- Remarks:
- No analytical determination was performed
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 604-144-0
- EC Number:
- 604-144-0
- Cas Number:
- 139525-77-2
- Molecular formula:
- C13H15NO.HCl
- IUPAC Name:
- 604-144-0
- Test material form:
- solid: particulate/powder
- Details on test material:
- White powder
Constituent 1
- Specific details on test material used for the study:
- Batch ; 839411/006Purity : 100.9%Storage : room temperature (20°C +/-5°C)
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Variety : Hamilton-BuchananAge : sexually immature young fish , lenght 2 +/- 1 cmSupplier : Dehner Garten-Center, D.67433 NeustadtDate of arrival : Sept 6th 2007Before being used for the test, the fish were kept for 14 days under test conditions. During this period, mortality didn't surpass 5%.
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- 24/ 48/ 72: 96 hours
Test conditions
- Test temperature:
- 20.3 - 20.4°C
- pH:
- 7.7 - 8.1
- Dissolved oxygen:
- 8.4 mg/L or 93%
- Nominal and measured concentrations:
- nomical : 1/ 10 / 100 mg/L
- Details on test conditions:
- Loading 1 fish/LVessels : glass aquaria, max volume 10 LAeration : accomplished with glass tubes, frequency of bubbles 1/sphotoperiod : 12/12 jours using neon tubesTemperature 23 +/- 1°CReplicates : one vessel, each containing 7 L test solution and 7 fishControl : one vessel, each containing 7 L dilution watert and 7 fish
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 - < 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- The mortality in the control may not exceed 10% at the end of the test. No mortalities occurred in the control.No mortality at 1 mg/L100% mortality at 10 mg/L (1 at 24h and 6 at 48h)100% mortality at 100 mg/L (7 at 24h )
- Reported statistics and error estimates:
- The validity criteria were met
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- According the guideline OECD 203, the following results for the test item Mephttamin HCL could be determined : 96h NOEC = 1 mg/L and 96h LC50 = 1 - 10 mg/L
- Executive summary:
The experiment was performed using three concentrations ranging from 1 to 100 mg/L. For each concentration, seven fish were exposed to the test item for 96 hours. The pH and the oxygen value of the water were normal.
In the treatment 10 and 100 mg/L 100% mortality was obersered. No mortality occured in the treatment 1 mg/L and in the control.
The following results for the test item Mephttamin HCL could be determined : 96h NOEC = 1 mg/L and 96h LC50 = 1 - 10 mg/L
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