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Diss Factsheets
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EC number: 946-992-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 14 1986 to May 28 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- The study was conducted in accordance with GLP and similar/equivalent OECD 404 guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,4-di-tert-pentylphenol
- EC Number:
- 204-439-0
- EC Name:
- 2,4-di-tert-pentylphenol
- Cas Number:
- 120-95-6
- Molecular formula:
- C16H26O
- IUPAC Name:
- 2,4-bis(1,1-dimethylpropyl)phenol
impurity 1
- Specific details on test material used for the study:
- The test material is a UVCB
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Rabbits were housed individually in cages sized in accordance with the "Guide for the Care and Use of Laboratory Animals" of the institute of Laboratory resources, National Research Council. Waste material was removed 3 times per week. Cages and feeders were sanitized every two weeks. Light cycle was 12hours light and 12hours dark. Food and water was provided ad libitum and checked daily, added or replaced as required.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5ml of the neat test material.
- Duration of treatment / exposure:
- The test material was applied and kept in contact with the skin for 4hours. At the end of the 4hrs exposure period, the wrapping were removed and skin wiped to remove remaining test material.
- Observation period:
- Animals were observed up to 14 days.
- Number of animals:
- six animals which includes 3 females and 3 males.
- Details on study design:
- The skin of each 6 adult abino rabbits were clipped free of fur. Test material was administered at one intact skin site. Following the application of the test material, one -inch square guaze patches were applied to each site. The trunk of each animal was then wrapped with a rubber dam and an Ace bandage to retard evaporation. The test material was kept in contact with the skin for 4hours. At the end of the 4hrs exposure period, the wrapping were removed and skin wiped to remove remaining test material.
Animals were observed for signs of erythema and edema and scored according to draize scale at 30-60minutes, 24 hours, 48 hours, 72 hours after application of test material and daily for 14days following application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 3.5
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: Necrosis, fissuring, and sloughing observed.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 2
- Reversibility:
- fully reversible within: 11 days
- Irritant / corrosive response data:
- Individual animal scores are given below for 30mins , 24 and 72 hours observations:
Endpoint TIME (hrs) Rabbit Number/Response
1 2 3 4 5 6
Erythema 24hrs 3 4 3 3 3 3
48hrs 3 4 3 3 3 4
72hrs 4 4 4 4 4 4
Edema 24hrs 4 4 4 4 4 4
48hrs 1 1 1 1 1 1
72hrs 1 1 1 1 1 1
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- The results from the study considers the test material to be skin corrosive. Therefore, in accordance with the criteria set in the CLP guidance document, the substance should be classified as Skin Corrosive, Category 1 C, H314.
- Executive summary:
The test substance was assessed for dermal corrosive effects on rabbit skin. Substance was applied to one intact skin site. Slight to severe erythema was observed throughout the study. Slight severe edema was observed through day 10. Necrosis, fissuring and sloughing were also observed and the study was terminated on day 14. Therefore, based upon the observations made in the acute dermal corrosion test in rabbits, the test substance was determined to be corrosive to the skin under CLP classification criteria.
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