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Diss Factsheets
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EC number: 202-864-6 | CAS number: 100-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2008-06-05 to 2008-07-03
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: Methods of Testing New Chemical Substances
- Version / remarks:
- version adopted 2006-11-20
(Nov21,2003; No.1121002, Pharmaceutical and Food safety bureau, ministry of health, laour and welfare;Nov.13, 2003, No.2, Manufacturing industries bureau, Ministry of Economy, trade and industry; No. 031121002) - Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Remarks:
- HPLC
- Details on sampling:
- Sampling at start of study (preparation of each test concentration) and at the end of exposure.
- Vehicle:
- no
- Details on test solutions:
- Stock solution: 2000 mg of test material were diluted with test water up to 1000 mL. (=> 2000mg/L, concentration 7)
The stock solution was further diluted with test water and test concentrations were prepared as 20, 43, 93, 200, 430, 930 mg/L (concentrations 1 to 6) - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: waterflea
- Strain/clone: STRAUS
- Source: National Institute for Environmental Studies
- Age: not older than 24 hours - Test type:
- static
- Water media type:
- freshwater
- Remarks:
- Elendt M4 medium
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 250 mg/L as CaCO3
- Test temperature:
- 20 ± 1 °C
- pH:
- 7.8 - 8.2
- Dissolved oxygen:
- 8.5 - 8.8 mg/L
- Salinity:
- NA
- Nominal and measured concentrations:
- Nominal concentrations: 20, 43, 93, 200, 430, 930, 2000 mg/L
Measured concentrations: 20.3, 44.0, 93.7, 201.0, 432.0, 920.0, 2020.0 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: beaker
- Material, size, headspace, fill volume: 100 mL, glass
- Aeration:
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light / 8 hours dark
- Light intensity: 800 lux - Reference substance (positive control):
- yes
- Remarks:
- Potassium dischromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 676 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% confidence limit: 449 - 1170 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 20.3 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- In the most recent test (9th - 11th Jan 2008) EC50 after 48 hrs exposure of potassium dichromate was measured as 0.76 mg test item /L (CI 95% 0.67 - 0.87 mg/L).
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48 h EC50 of the test item on Daphnia magna was determined to be 676 mg/L.
- Executive summary:
In the acute immobilisation test (reference 6.1.3-1) with Daphnia magna (STRAUS), the effects of the test item were determined according to Methods of Testing New Chemical Substances <Algal Growth Inhibition Test, Daphnia Acute Immobilization Test, and Fish Acute Toxicity Test> (Nov 21,2003; No.1121002, Pharmaceutical and Food safety bureau, ministry of health, laour and welfare; Nov 13, 2003, No.2, Manufacturing industries bureau, Ministry of Economy, trade and industry; No. 031121002).The study was conducted in a static system over a period of 48 hours with nominal concentrations 20, 43, 93, 200, 430, 930, 2000 mg/L. The validity criteria of the test guideline were fulfilled. The estimated EC50 value (48 hours) of the test item is 676 mg/L.
Reference
Description of key information
The 48-h EC50 of the test item on Daphnia magna was determined to be 676 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 676 mg/L
Additional information
In the acute immobilisation test (reference 6.1.3-1) with Daphnia magna (STRAUS), the effects of the test item were determined according to Methods of Testing New Chemical Substances <Algal Growth Inhibition Test, Daphnia Acute Immobilization Test, and Fish Acute Toxicity Test> (Nov 21, 2003; No.1121002, Pharmaceutical and Food safety bureau, ministry of health, laour and welfare; Nov 13, 2003, No.2, Manufacturing industries bureau, Ministry of Economy, trade and industry; No. 031121002). The study was conducted in a static system over a period of 48 hours with nominal concentrations 20, 43, 93, 200, 430, 930, 2000 mg/L. The validity criteria of the test guideline were fulfilled. The estimated EC50 value (48 hours) of the test item is 676 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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