Registration Dossier
Registration Dossier
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EC number: 215-709-2 | CAS number: 1344-81-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Remarks:
- Tessenderlo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA Pesticide Assessment Guidelines, Subdivision F, Hazard Evaluation, Human and Domestic Animals, November 1984
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- traditional method
Test material
- Reference substance name:
- Calcium sulfide (Ca(Sx))
- EC Number:
- 215-709-2
- EC Name:
- Calcium sulfide (Ca(Sx))
- Cas Number:
- 1344-81-6
- Molecular formula:
- CaSx (X=2,3,4,5,6,7)
- IUPAC Name:
- Calcium sulfide (Ca(Sx)
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Hilltop Lab Animals, Scottdale, PA (15 males and 15 females)
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- clean air
- Mass median aerodynamic diameter (MMAD):
- >= 1.8 - <= 2.35 µm
- Details on inhalation exposure:
- See it in the attachement page 17-18
- Duration of exposure:
- ca. 4.5 h
- Concentrations:
- 2.41 mg/l , 3.78 mg/l and 5.08 mg/l
- No. of animals per sex per dose:
- 5 female and 5 male rats
- Control animals:
- no
- Statistics:
- Probit Analysis
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 3.6 mg/L air (nominal)
- Based on:
- test mat.
- 95% CL:
- >= 2.93 - <= 4.42
- Exp. duration:
- 4.5 h
- Mortality:
- At 2.41 mg/l the mortality is 30%
At 3.78 mg/l the mortality is 40%
At 5.08 mg/l the mortality is 80%
See it in the attachement on Page 30 Table 11 - Clinical signs:
- other: At 2.41 mg/l at 12 page Exposure level 2nd paragraph At 3.78 mg/l at 13. page Exposure level 2nd paragraph At 5.08 mg/l at 13. page Exposure level 2nd paragraph
- Body weight:
- Measured but not evaluated.
- Gross pathology:
- At 2.41 mg/l the 12 page Exposure level 3rd paragraph
At 3.78 mg/l the 13 page Exposure level 3rd paragraph
At 5.08 mg/l the 14 page Exposure level 3rd paragraph
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- H332
- Conclusions:
- LC50: 3.6 mg/l See it in the attachement on page 14 in the conclusion.
- Executive summary:
It is classified as acute tox inhalation category 4 (H332).
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