Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-352-0 | CAS number: 139-08-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 19, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: Laser scattering/diffraction and sieving
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
- Mass median aerodynamic diameter:
- ca. 35.6 µm
- Geometric standard deviation:
- ca. 0.11
- Remarks on result:
- other: median particle size of the fine fraction
- Key result
- Percentile:
- D10
- Mean:
- ca. 10.8 µm
- St. dev.:
- 0.5
- Key result
- Percentile:
- D50
- Mean:
- ca. 35.6 µm
- St. dev.:
- 0.11
- Key result
- Percentile:
- D90
- Mean:
- ca. 106.5 µm
- St. dev.:
- 0.1
- No.:
- #1
- Size:
- < 250 µm
- Distribution:
- ca. 35.1 %
- No.:
- #2
- Size:
- < 200 µm
- Distribution:
- ca. 34.9 %
- No.:
- #3
- Size:
- < 100 µm
- Distribution:
- ca. 31 %
- No.:
- #4
- Size:
- < 50 µm
- Distribution:
- ca. 22.4 %
- No.:
- #5
- Size:
- < 10 µm
- Distribution:
- ca. 2.9 %
- Conclusions:
- Under the study conditions, the particle size distribution of the test substance was found to be: 65% > 2000 µm and 35% < 2000 µm (35%<250 µm; 35% of <200 µm; 31% <100 µm; 22.4% <50 µm), 2.9% < 10 µm. The median particle size (D50) of the fine particles were determined to be 36 µm.
- Executive summary:
A study was conducted to determine the particle size distribution of the test substance, C14 ADBAC, using laser scattering/diffraction method, according to the OECD Guideline 110, EPA OPPTS 830.7520 and ISO 13320, in compliance with GLP. Before the measurements, the test substance was sieved through a 2000 um sieve and the coarse fraction (with a particle size of >2000 µm) was found to be 64.9% and a fine fraction (with a particle size <2000 µm) was found to be 35.1%. The fine fraction was determined to have a median particle size D50 = 36 µm, which was determined by laser diffraction measurement. The mean D10, D50 and D90 (distribution type: volume) diameters applying the Fraunhofer particle model were determined to be 10.8, 35.6 and 106.5 µm respectively. According to the results of the laser diffraction measurement and the sieving, the test substance contains particles with a size of <250 µm of 35.1%, with a size of <200 µm of 34.9%, with a size of <100 µm of 31.0%, with a size of <50 µm of 22.4% with a size of <10 µm of 2.9%. Under the study conditions, the particle size distribution of the test substance was found to be: 65% > 2000 µm and 35% <2000 µm (35% <250 µm; 35% of <200 µm; 31% <100 µm; 22.4% <50 µm), 2.9% <10 µm. The median particle size (D50) was determined to be 36 µm (Moller, 2018).
According to R.7c Guidance, in humans, particles with aerodynamic diameters below 100 μm have the potential to be inhaled. Particles with aerodynamic diameters below 50 μm may reach the thoracic region and those below 15 μm the alveolar region of the respiratory tract. Therefore, based on the results of the study, about 90% of the substance, have a particle size >100 µm, hence are not available as inhalable fraction. Only around 8%, with a particle size <50 µm (median diameter of 36 µm), may reach the thoracic region and around 3%, may reach the alveolar region of the respiratory tract.
Reference
Results
Particle Size Distribution
Two test series of 3 measurements each were performed with the fine fraction of the test substance.
Test series 1:
D10: 11.2 µm
D50: 36.6 µm (Median diameter)
D90: 106.4 µm
Test series 2:
D10: 10.3 µm
D50: 34.5 µm (Median diameter)
D90: 106.5 µm
Average
D10: 10.8 µm
D50: 35.6 µm (Median diameter)
D90: 106.5 µm
Final Results
The test substance has a coarse fraction with a particle size of >2000 µm of 64.9 % and a fine fraction with a particle size <2000 µm of 35.1 %. The fine fraction has a median particle size D50 = 36 µm, which was determined by laser diffraction measurement. According to the results of the laser diffraction measurement and the sieving, the test substance contains particles with a size of <250 µm of 35.1 %, with a size of <200 µm of 34.9 %, with a size of <100 µm of 31.0 %, with a size of <50 µm of 22.4 % with a size of <10 µm of 2.9 %.
Description of key information
Particle size distribution of the test substance was determined using laser scattering/diffraction and sieving methods, according to the OECD Guideline 110, (Moller, 2018).
Additional information
Particle size distribution: 65% > 2000 µm and 35% < 2000 µm (35% <250 µm; 35% of <200 µm; 31% <100 µm; 22.4% <50 µm), 2.9% < 10 µm; median particle size (D50) of fine fraction: 36 µm
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.