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Diss Factsheets
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EC number: 204-429-6 | CAS number: 120-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The SIDS dossier assigns a reliability of 1, valid without restrictions to this reference.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2,4-dichlorophenol
- EC Number:
- 204-429-6
- EC Name:
- 2,4-dichlorophenol
- Cas Number:
- 120-83-2
- Molecular formula:
- C6H4Cl2O
- IUPAC Name:
- 2,4-dichlorophenol
- Details on test material:
- The purity of the test substance is reported to be 99.6%.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No additional details presented.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- Substance melted.
- Duration of exposure:
- Up to 9 days
- Doses:
- The dose levels were 200-300-1400 and 2000 mg/kg in males (5 animals/dose) and 200 and 2000 mg/kg in females (5 animals/dose).
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- The test substance was melted at 40 °C to obtain the liquid form to be tested. This was done in order to obtain a more pronounced toxic effect which can mimic accidents. The substance was applied under semi-occlusive patches during 24 h to the skin of Sprague-Dawley rats at a volume taking into consideration the density of the substance (d=1.38). The dose levels were 200-300-1400 and 2000 mg/kg in males (5 animals/dose) and 200 and 2000 mg/kg in females (5 animals/dose). The treated skin surface ranges between 2cm2 (200 mg/kg dose) and 30-35cm2 (2000 mg/kg dose).
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No preliminary study reported.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 780 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were 4/5 deaths at the highest dose level in both males and females. Death occurred within 6 days after application.
- Clinical signs:
- other: Slight decrease in motor activity was noted from 200 mg/kg and was no longer present 24 hours after application. Marked decrease in motor activity and respiratory impairment was observed from 300 mg/kg and 1400 mg/kg ; these signs were still present up to
- Other findings:
- At necropsy, presence of a liquid black in color in the urinary bladder of one male and one female at 2000 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 was determined to be 780 mg/kg/bw
- Executive summary:
The test substance was subjected to an acute dermal toxicity study according to OECD guideline 402. The study was performed to GLP. The LD50 was determined to be 780 mg/kg/bw. In addition, at all doses, marked to severe irritation resulting in skin necrosis was noted after removal of the patch, which was hardly reversible within 2 weeks.
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