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Diss Factsheets
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EC number: 229-043-5 | CAS number: 6407-78-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- REPORTS of the Scientific Committee on Cosmetology (seventh series)
- Author:
- European Commission (EC) - Scientific Committee on Cosmetology (SCC)
- Year:
- 1 988
- Bibliographic source:
- COMMISSION OF THE EUROPEAN COMMUNITIES; Brussels, Luxembourg, 1988.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin irritation study of chemical C.I. Pigment Red 3(CAS No: 2425-85-6) was conducted on abraded and non abraded skin of rabbits under occlusive condition to assess the skin irritancy of test chemical.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-(4-methyl-2-nitrophenylazo)-2-naphthol
- EC Number:
- 219-372-2
- EC Name:
- 1-(4-methyl-2-nitrophenylazo)-2-naphthol
- Cas Number:
- 2425-85-6
- Molecular formula:
- C17H13N3O3
- IUPAC Name:
- 1-(4-Methyl-2-nitrophenylazo)-2-naphthol
- Test material form:
- solid
- Details on test material:
- - Name of test material: C.I. Pigment Red 3
- Molecular formula: C17H13N3O3
- Molecular weight: 307.308 g/mol
- Substance type: organic
- Physical state: solid
- Smiles: c12c(\N=N\c3c(cc(C)cc3)[N+](=O)[O-])c(ccc1cccc2)O
- InChI: 1S/C17H13N3O3/c1-11-6-8-14(15(10-11)20(22)23)18-19-17-13-5-3-2-4-12(13)7-9-16(17)21/h2-10,21H,1H3/b19-18+
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: C.I. Pigment Red 3
- Molecular formula: C17H13N3O3
- Molecular weight: 307.308 g/mol
- Substance type: organic
- Physical state: solid
- Smiles: c12c(\N=N\c3c(cc(C)cc3)[N+](=O)[O-])c(ccc1cccc2)O
- InChI: 1S/C17H13N3O3/c1-11-6-8-14(15(10-11)20(22)23)18-19-17-13-5-3-2-4-12(13)7-9-16(17)21/h2-10,21H,1H3/b19-18+
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No Data Available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: Abraded and non abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- Amount : 500mg
concentration applied: 100% - Duration of treatment / exposure:
- No Data Available
- Observation period:
- No Data Available
- Number of animals:
- No Data Available
- Details on study design:
- No Data Available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Negative effects were observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material C.I. Pigment Red 3(CAS No: 2425-85-6) was considered to be not irritating to the abraded and non abraded skin of rabbits under occlusive condition.
- Executive summary:
Skin irritation study of chemical C.I. Pigment Red 3(CAS No: 2425-85-6) was conducted on rabbits to assess its skin irritancy.
TheC.I. Pigment Red 3 was applied on abraded and non abraded skin of each rabbits under occlusive condition.
No indication of skin irritation was observed. Hence the chemical C.I. Pigment Red 3(CAS No: 2425-85-6)was considered to be not irritating to theabraded and non abraded skin of rabbits under occlusive condition.
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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