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EC number: 241-010-7 | CAS number: 16941-12-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Early guideline study (US Department of Transportation), prior to GLP, scientifically acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US Code of Federal Regulation, Title 49, Part 173, Appendix A, 27th September, 1976, Department of Transportation
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Hexachloroplatinic acid
- EC Number:
- 241-010-7
- EC Name:
- Hexachloroplatinic acid
- Cas Number:
- 16941-12-1
- Molecular formula:
- Cl6Pt.2H
- IUPAC Name:
- platinum(4+) dihydrogen hexachloride
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Chloroplatinic acid
- Substance type: No data
- Physical state: crystalline material
- Analytical purity: not stated
- Impurities (identity and concentrations): not stated
- Lot/batch No.: not stated
- Stability under test conditions: not stated
- Storage condition of test material: not stated. Material supplied in screw capped glass bottle
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Healthy female rabbits from "recognised breeders"
- Age at study initiation: 16 - 18 weeks
- Weight at study initiation: mean 2.5 kg
- Housing: caged in environmentally controlled room
- Diet (e.g. ad libitum): commercial rabbit diet (Rank Hovis MacDougal)
- Water (e.g. ad libitum): filtered, ad libitum
- Acclimation period: not stated
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not stated
- Humidity (%): not stated
- Air changes (per hr): not stated
- Photoperiod (hrs dark / hrs light): natural lighting
IN-LIFE DATES: From: To:
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- test material applied as supplied (crystalline material)
- Controls:
- no
- Amount / concentration applied:
- 0.5 g/test site
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Assessed for necrosis and ulceration, immediately after the end of treatment (4 hours) and at 48 hours and 7 days after the start of treatment.
- Number of animals:
- 6
- Details on study design:
- Area of the back of each rabbit (at least 10% of body surface) was shaved 24 hours prior to treatment. One test site over the mid-line on each rabbit. 0.5 g test material applied to each test site on a gauze pad 2.5 x 2.5 cm. Pads secured with occlusive tape and dressings and left in place for 4 hours.
Assessed for necrosis and ulceration, immediately after the end of treatment (4 hours) and at 48 hours and 7 days after the start of treatment.
No control sites or animals were incorporated into the test
Criteria for classification as corrosive included destruction or irreversible alteration of the tissue, where tissue destruction involved ulceration or necrosis at any reading, not merely sloughing of the epidermis, erthyema, oedema or fissuring.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: assessment for corrosivity
- Basis:
- other: assessment of necrosis and ulceration in 6 rabbits
- Time point:
- other: 4 hours, 48 hours, 7 days
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Remarks:
- Irritation was observed at the 4-hr time point in four animals. After 48 hr this had developed into necrosis in five animals, which was still evident at the end of the observation period. One animal was unaffected by treatment at every time point.
- Irritant / corrosive response data:
- One animal was unaffected by treatment at every timepoint.
Results from the remaining 5:
At 4 hours, 4/5 animals had skin irritation and 1/5 was unaffected.
At 48 hours, 5/5 animals had at least 1 area of necrotic tissue.
At 7 days, necrosis was maintained in 5/5 animals.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: other: US Federal Register Corrosivity Test (1976)
- Conclusions:
- In an early US guideline study, irreversible necrosis was observed following a single 4-hr occluded application of chloroplatinic acid to the skin of six rabbits.
- Executive summary:
In an early US guideline study, the skin irritant potential of chloroplatinic acid was assessed in six female New Zealand White rabbits. The test material (0.5 g, crystalline solid) was applied to shaved intact skin for 4 hr under occlusion. The sites were assessed for evidence of necrosis or ulceration immediately upon removal of the patch, with further assessments made at 48 hours and 7 days after application of the test material.
Irritation was observed at the 4-hr time point in four animals. After 48 hr this had developed into necrosis in five animals, which was still evident at the end of the observation period. One animal was unaffected by treatment at every time point.
Based on the results of this study, the test material should be classified as corrosive to skin (at least category 1C) under EU CLP criteria (EC 1272/2008).
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