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EC number: 500-133-9 | CAS number: 56641-05-5 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study followed the guideline; DIN 38412-9 (1989-05) German Standard Methods For Examination Of Water, Waste Water & Sludge; Bio Assays (group L); Determination Of Inhibitory Effects Of Water Constituents On The Growth Of Scenedesmus Green Algae (l9)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- ISO 8692 (Water Quality - Fresh Water Algal Growth Inhibition Test with Scenedesmus subspicatus and Selenastrum capricornutum)
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38412 L9
- GLP compliance:
- not specified
- Details on sampling:
- samples analyzed at 0h, 24h, 48h 72h and 96h.
- Details on test solutions:
- Concentration range; 0.5 mg/l to 25 mg/l.
No other vehicle than water.
water solubility in stock solution 40 g/l - Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- Obtained from Algensammlung Göttingen SAG 86.81
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 21 C (+/- 2oC)
- pH:
- 7.25-7.98
- Nominal and measured concentrations:
- Nominal concentrations; 0.5-25 mg/l
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.71 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 0.19-2.61
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 1.87-10.3
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.11 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 0.03-0.38
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 1.02-2.84
- Duration:
- 96 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.42 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 0.23-0.76
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 2.98-5.66
- Duration:
- 96 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.14 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 0.04-0.43
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.33 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 0.77-2.28
- Executive summary:
EC10 and EC50 values for the toxicity of phenoxyethylacrylate to the freshwater greenalgae Desmodesmus subcapitatus was established at 72 and 96h hours, both in terms of biomass and growth rate. The testsytem was equal to ISO 8692 and a positive control ensured that the system was valid. EC 10 (96h) were 0.14 and 0.42 mg/l, and EC 50 (96h) were 1.33 and 4.1, when based on biomass and growth rate, respectively. EC10 (72 h) was 0.71 based on growth rate and EC50 (72 h) was 4.44 based on growth rate.
No data on marine algae have been identified.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across to study with high reliability
- Justification for type of information:
- Data on target substance not available. Thus, read-across has been applied using data from source substances (S1).
See further read-acoss justification in attached document to section 13. - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.71 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 0.19-2.61
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 1.87-10.3
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.11 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 0.03-0.38
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 1.02-2.84
- Duration:
- 96 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.42 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 0.23-0.76
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 2.98-5.66
- Duration:
- 96 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.14 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 0.04-0.43
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.33 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 0.77-2.28
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- No data is available for Phenol, ethoxylated, esters with acrylic acid (M142) (T).
Toxicity of 2-phenoxyethyl acrylate to the freshwater green algae Desmodesmus subcapitatus was tested according to a test guideline equal to ISO 8692 and a positive control ensured that the system was valid. EC10 (96h) were 0.14 and 0.42 mg/l, and EC 50 (96h) were 1.33 and 4.1, when based on biomass and growth rate, respectively. EC10 (72 h) was 0.71 based on growth rate and EC50 (72 h) was 4.44 based on growth rate.
Due to structural and pysico-chemical similarity to Phenol, ethoxylated, esters with acrylic acid, equal EC10 (72h and 96h) and EC50 (72h and 96h) can also be concluded for Phenol, ethoxylated, esters with acrylic acid as well. - Executive summary:
No data is available for Phenol, ethoxylated, esters with acrylic acid (M142) (T).
Toxicity of 2-phenoxyethyl acrylate to the freshwater green algae Desmodesmus subcapitatus was tested according to a test guideline equal to ISO 8692 and a positive control ensured that the system was valid. EC10 (96h) were 0.14 and 0.42 mg/l, and EC50 (96h) were 1.33 and 4.1, when based on biomass and growth rate, respectively. EC10 (72 h) was 0.71 based on growth rate and EC50 (72 h) was 4.44 based on growth rate.
Due to structural and pysico-chemical similarity to Phenol, ethoxylated, esters with acrylic acid, equal EC10 (72h and 96h) and EC50 (72h and 96h) can also be concluded for Phenol, ethoxylated, esters with acrylic acid as well.
See justification for read-across attached in section 13.
Referenceopen allclose all
Description of key information
EC10 and EC50 values for the toxicity of phenoxyethylacrylate to the freshwater greenalgae Desmodesmus subcapitatus was established at 72 and 96h hours, both in terms of biomass and growth rate.
Due to structural similarity, the same EC10 and EC50 values were concluded for Phenol, ethoxylated, esters with acrylic acids as well.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 4.44 mg/L
- EC10 or NOEC for freshwater algae:
- 0.71 mg/L
Additional information
EC10 and EC50 values for the toxicity of phenoxyethylacrylate to the freshwater greenalgae Desmodesmus subcapitatus was established at 72 and 96h hours, both in terms of biomass and growth rate. The test system was equal to ISO 8692 and a positive control ensured that the system was valid. EC10 (96h) were 0.14 and 0.42 mg/l, and EC50 (96h) were 1.33 and 4.1, when based on biomass and growth rate, respectively. EC10 (72 h) was 0.71 based on growth rate and EC50 (72 h) was 4.44 based on growth rate.
No data on marine algae have been identified.
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