Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-735-9 | CAS number: 70-47-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Biodegradation in water: screening tests:
- published data: sufficiently documented non-GLP, non-guideline study, RL2, exposure of the test item (500 mg/L) to activated sludge solids at 2500 mg/L in the Warburg respirometer, measurement of oxygen uptake, oxygen uptake in %: 24.7 within 24h, readily biodegradable
- QSAR prediction with the Estimation Programs Interface (EPI) SuiteTM v4.1 containing BIOWIN models 1 -7 (v4.1), RL2, substance falls within the applicability domain, readily biodegradable
Hydrolysis:
- not necessary because the substance is readily biodegradable
Adsorption/desorption:
- no test necessary: the substance exhibits a low logKow (-3.82) and therefore adsorption is not expected.
Additional information
For the assessment of biodegradability of L-asparagine are no GLP and OECD compliant studies available. There is one publication with sufficient documentation conducted with scientifically accepted methods that is regarded acceptable for assessment.
In a published study of Malaney and Gerhold the biological oxygen demand, i.e. the concentration of oxygen in mg/L required to oxidize 500 mg/L of substrate completely, of activated sludge incubated with L-asparagine was determined. The result reveals that 24.7 % of the compound were degraded within 24 h, therefore L-asparagine is considered to be readily biodegradable.
The result reveals that 24.7 % of the compound were degraded within 24 h, indicating that L-asparagine can be considered to be readily biodegradable. The very good biodegradability was forseeable as the substance is a natural constituent of living cells and is involved in many metabolic pathways. More, many microorganisms use the substance as carbon and nitrogen source for growth.
Additionally, a QSAR estimation was performed with the Estimation Programs Interface (EPI) SuiteTM v4.1 containing BIOWIN models 1 -7 (v4.1). The substance is predicted to be readily biodegradable supporting the experimental data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.