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EC number: 214-540-1 | CAS number: 1143-72-2
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-08-31 - 2016-02-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- ca. 104 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 20 °C
- Remarks on result:
- other: pH at 23 °C was 5.7
- Conclusions:
- The water solubility cs of the test item at a temperature of 20 °C was determined to be cs=104 mg/L (+/-2.5 mg/L).
- Executive summary:
A study was conducted in accordance with OECD TG 105 and Regulation (EC) No 440/2008 method A.6 to determine the water solubility of the test substance using the flask method. The preliminary test showed that the water solubility of the test item was < 1.0 g/L. The water solubility cs of the test item at a temperature of 20 °C was determined to be cs=104 mg/L (+/-2.5 mg/L).
Reference
Results
Preliminary visual estimation
Water solubility appeared to be < 10 mg/L, therefore the column elution
method was used. This study showed that the water solubility was > 10
mg/L so a further preliminary estimation was done so as to determine the
test item quantity necessary to saturate the desired volume of water for
the flask method.
Table 1 – Preliminary visual estimation results
Test item amount [mg] |
Added volume of distilled water [mL] |
Total volume [mL] |
Mixture appearance |
103.3 |
0.1 |
0.1 |
Not dissolved |
0.4 |
0.5 |
||
0.5 |
1.0 |
||
1.0 |
2.0 |
Light yellow solution, not completely dissolved |
|
8.0 |
10.0 |
||
90.0 |
100.0 |
The preliminary visual experiments showed that water solubility of the test item is < 1 g/L. Therefore, the flask method was used.
Flask Method
Table 2 – Water solubility experiments
Experiment |
24 h experiment |
48 h experiment |
72 h experiment |
Blank experiment (72 h) |
Test item amount [g] |
0.261 |
0.260 |
0.258 |
-- |
Distilled water amount [mL] |
50 |
|||
Stirring time at 30 °C [h] |
24 |
48 |
72 |
72 |
pH at 23 °C |
5.7 |
5.2 |
||
Aliquots of flasks [mL] |
0.05 |
|||
1stdilution to volume [mL] |
1 |
|||
Dilution factor |
20 |
|||
Measured concentration [mg/L] |
5.098 |
5.327 |
5.134 |
-- |
Mean concentration [mg/L] |
5.089 |
5.321 |
5.132 |
-- |
Water solubility [mg/L] |
101.8 |
106.4 |
102.6 |
-- |
The water solubility of the test item at 20 °C was determined to be equal to 104 mg/L (± 2.5 mg/L).
Description of key information
The water solubility cs of the test item at a temperature of 20 °C was determined to be cs=104 mg/L (+/-2.5 mg/L).
Key value for chemical safety assessment
- Water solubility:
- 104 mg/L
- at the temperature of:
- 20 °C
Additional information
A study was conducted in accordance with OECD TG 105 and Regulation (EC) No 440/2008 method A.6 to determine the water solubility of the test substance using the flask method. The preliminary test showed that the water solubility of the test item was < 1.0 g/L. The water solubility cs of the test item at a temperature of 20 °C was determined to be cs=104 mg/L (+/-2.5 mg/L).
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