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Diss Factsheets
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EC number: 202-896-0 | CAS number: 100-86-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VIII
- Author:
- Carpenter, Weil and Smyth.
- Year:
- 1 974
- Bibliographic source:
- Toxicol Appl Pharmacol 28, 313-319.
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth Jr., Carpenter, Well, Pozzani and Striegel.
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 23:2, 95-107
- Reference Type:
- publication
- Title:
- Chemical Burns of the Rabbit Cornea
- Author:
- Carpenter and Smyth
- Year:
- 1 946
- Bibliographic source:
- American Journal of Ophthalmology Vol. 29 (11), Pages 1363-1372
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The method is described in Smyth et al., 1962 and Carpenter and Smyth 1946. Eye irritation was evaluated using 5 albino rabbits per dose. The test material was applied to the centre of the cornea while the lids are retracted, and approximately 1 minute later, the lids are released. The eye was examined in strong diffuse daylight 18 - 24 hours later, stained with fluorescein, and the injury scored. No vehicle was used.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methyl-4-phenylbutan-2-ol
- EC Number:
- 203-074-4
- EC Name:
- 2-methyl-4-phenylbutan-2-ol
- Cas Number:
- 103-05-9
- Molecular formula:
- C11H16O
- IUPAC Name:
- 2-Methyl-4-phenyl-2-butanol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- Undiluted
- Duration of treatment / exposure:
- 18 - 24 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: corneal necrosis
- Basis:
- mean
- Time point:
- other: Only 24hr timepoint
- Score:
- 8
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
Applicant's summary and conclusion
- Interpretation of results:
- other: irritating
- Conclusions:
- Phenylethyl Alcohol is an irritant to rabbit eyes.
- Executive summary:
In an eye irritation study (Carpenter et al., 1974) Phenylethyl Alcohol (undiluted) was applied to the centre of the cornea of 5 albino rabbits. The eye was examined in strong diffuse daylight 18 - 24 hours later, stained with fluorescein, and the injury scored. No vehicle was used.
Eye injury was graded according to the following 10-point scale based upon the degree of corneal necrosis that resulted. The corneal injury in rabbits was indicated as 8 out of 10. Based on the results of this study, Phenylethyl Alcohol was considered to be an eye irritant.
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