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EC number: 240-834-4 | CAS number: 16803-97-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Justification for type of information:
- Data is from study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute oral toxicity test of 4-amino-N-(4-aminophenyl)benzenesulphonamide (16803-97-7) in Rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 4-amino-N-(4-aminophenyl)benzenesulphonamide
- EC Number:
- 240-834-4
- EC Name:
- 4-amino-N-(4-aminophenyl)benzenesulphonamide
- Cas Number:
- 16803-97-7
- Molecular formula:
- C12H13N3O2S
- IUPAC Name:
- 4-amino-N-(4-aminophenyl)benzenesulphonamide
- Details on test material:
- Name - 4-amino-N-(4-aminophenyl)benzenesulphonamide
InChI - 1S/C12H13N3O2S/c13-9-1-3-10(4-2-9)15-11-5-7-12(8-6-11)18(14,16)17/h1-8,15H,13H2,(H2,14,16,17)
Smiles - O=S(=O)(c1ccc(cc1)Nc1ccc(cc1)N)N
Mol. formula: C12H13N3O2S
Molecular Weight - 263.32 g/mole
Constituent 1
- Specific details on test material used for the study:
- Name - 4-amino-N-(4-aminophenyl)benzenesulphonamide
InChI - 1S/C12H13N3O2S/c13-9-1-3-10
(4-2-9)15-11-5-7-12(8-6-11)18(14,16)17/h1-8,15H,13H2,(H2,14,16,17)
Smiles - O=S(=O)(c1ccc(cc1)Nc1ccc(cc1)N)N
Mol. formula: C12H13N3O2S
Molecular Weight - 263.32 g/mole
Purity - 90-95%
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: SPF-breeding: Company WIGA, Sulzfeld
- Weight at study initiation: male animals -222 g, female animals -182 g
- Diet (e.g. ad libitum): The rats received Altromin-R ad libitum
- Water (e.g. ad libitum):ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10000, 6400, 3200 and 1600 mg/kg
- Amount of vehicle (if gavage): The product was administered once in different doses as 16 and 20 % aqueous suspension (w / v) with carboxymethylcellulose through the gavage
MAXIMUM DOSE VOLUME APPLIED: 10000mg/kg - Doses:
- 10000, 6400, 3200 and 1600 mg/kg
- No. of animals per sex per dose:
- Total = 20 (Male/Female)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortality was observed at 1, 24 and 48 h as well as after 7 and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: Animals were observed for symptoms of intoxication, macroscopical examination. - Statistics:
- The median lethal dose (LD50) was calculated according to LITCHFIELD and WILCOXON.
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 7 100 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 5 504 - 9 159
- Remarks on result:
- other: 50% mortality observed
- Mortality:
- At 6400 mg/kg - Female: 1/5 died at 48 hours and 3/5 died at 7 days; Male: 1/5 died at 48 hours.
At 10000 mg/kg - Female: 1/5 died at 24 hours, 4/5 at 48 hours and 5/5 at 7 days period; Male: 2/5 died at 24 hours, 3/5 died at 48 hours and 3/5 died at 7 days period. - Clinical signs:
- other: Symptoms of poisoning such as dyspnea, apathy, bitten tails, dark yellow urin, calm behavior, slight tumbling was observed in animals.
- Gross pathology:
- In Died animals - acute stasis hyperemia, acute cardiac dilation, Liver clay gray, a bit bright Kidneys were observed.
In Killed animals - Internal organs were found without any pathological findings after macroscopic examination. - Other findings:
- No data
Any other information on results incl. tables
Table - Mortality
Dose mg/kg |
Conc. % |
Animal number |
dies within |
||||
1 Hour |
24 Hours |
48 Hours |
7 Days |
14 Days |
|||
10000 |
20 |
5 M 5 F |
0/5 0/5 |
2/5 1/5 |
3/5 4/5 |
3/5 5/5 |
3/5 5/5 |
6400 |
5 M 5 F |
0/5 0/5 |
1/5 0/5 |
1/5 1/5 |
1/5 3/5 |
1/5 3/5 |
|
3200 |
5 M 5 F |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
|
1600 |
16 |
5 M 5 F |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
LD 50: 7100 (5504 - 9159) mg/kg
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 was considered to be 7100 mg/kg bw with the confidential limit of 5504 – 9159mg/kg, when Sprague-Dawley male and female rats were treated with 4-amino-N-(4-aminophenyl)benzenesulphonamide via oral gavage route.
- Executive summary:
The acute oral toxicity of 4-amino-N-(4-aminophenyl)benzenesulphonamide (16803-97-7) was tested in Sprague-Dawley male and female rat at the dose concentration of 10000, 6400, 3200 and 1600 mg/kg bw at 16 and 20 % aqueous suspension (W / v) with Carboxymethylcellulose. The test substance (90-95%) was applied through the gavage route. The animals was taken from SPF-breeding:Company WIGA,Sulzfeld of body weight-male animals 222g and female animals-182g. The rats received Altromin-R from the company Altrogge, Lage / Lippe, and water ad libitum. Mortality was observed at 1, 24 and 48 h as well as after 7 and 14 days. Animals were observed for symptoms of intoxication, macroscopical examination.The median lethal dose (LD50) was calculated according to LITCHFIELD and WILCOXON.50% mortality observed at 7100(5504-9159) mg/kg bw. Symptoms of poisoning such as dyspnea, apathy, bitten tails, dark yellow urin, calm behavior, slight tumbling was observed in animals. In Died animals - acute stasis hyperemia, acute cardiac dilation, Liver clay gray, a bit bright Kidneys were observed. In Killed animals - Internal organs were found without any pathological findings after macroscopic examination.Therefore, LD50 was considered to be 7100 mg/kg bw with the confidential limit of 5504 – 9159mg/kg, when Sprague-Dawley male and female rats were treated with 4-amino-N-(4-aminophenyl)benzenesulphonamide via oral gavage route.
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