Registration Dossier
Registration Dossier
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EC number: 226-237-1 | CAS number: 5332-24-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of 1-Chloro-4-nitrobenzene (100-00-5)
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017
- Reference Type:
- secondary source
- Title:
- NTP Technical Report on Toxicity Studies of 2-Chloronitrobenzene and 4-Chloronitrobenzene (CAS Nos. 88-73-3 and 100-00-5)
- Author:
- National Toxicology Program
- Year:
- 1 993
- Bibliographic source:
- National Institutes of Health, National Toxicology Program Toxicity Report Series Number 33, NIH Publication 93-3382, July 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of 1-Chloro-4-nitrobenzene (100-00-5) in rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1-chloro-4-nitrobenzene
- EC Number:
- 202-809-6
- EC Name:
- 1-chloro-4-nitrobenzene
- Cas Number:
- 100-00-5
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-Chloro-4-nitrobenzene
- Details on test material:
- - IUPAC Name: 1-Chloro-4-nitrobenzene
- Common Name: 4-Chloronitrobenzene
- Mol. formula: C6H4ClNO2
- Molecular Weight: 157.556 g/mole
- Smiles: c1([N+](=O)[O-])ccc(Cl)cc1
- InChI: 1S/C6H4ClNO2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H
Constituent 1
- Specific details on test material used for the study:
- - IUPAC Name: 1-Chloro-4-nitrobenzene
- Common Name: 4-Chloronitrobenzene
- Mol. formula: C6H4ClNO2
- Molecular Weight: 157.556 g/mole
- Smiles: c1([N+](=O)[O-])ccc(Cl)cc1
- InChI: 1S/C6H4ClNO2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 3040 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 040 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality observed
- Mortality:
- 50% mortality observed at 3040 mg/kg bw
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 value was considered to be 3040 mg/kg bw, when rabbits were treated with 1-Chloro-4-nitrobenzene by dermal application.
- Executive summary:
Acute dermal toxicity study was done in rabbits using 1-Chloro-4-nitrobenzene. 50% mortality was observed at dose 3040mg/kg bw. Hence, the LD50 value was considered to be 3040 mg/kg bw, when rabbits were treated with 1-Chloro-4-nitrobenzene by dermal application.
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