Registration Dossier
Registration Dossier
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EC number: 248-895-9 | CAS number: 28198-05-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from authoritative database
- Justification for type of information:
- Data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative database
- Title:
- RTECS Number: CB6680000
- Author:
- RTECS database
- Year:
- 2 017
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1329, 1986.
- Reference Type:
- publication
- Title:
- "Prehled Prumyslove Toxikologie; Organicke Latky"
- Author:
- Marhold, J.
- Year:
- 1 986
- Bibliographic source:
- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1329, 1986.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: refer below
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of 1,2-dihydroxy-5,8-bis(4-hydroxyanilino)anthracene-9,10-dione (CAS No. 6425-07-6) in rat by the oral route.
- GLP compliance:
- not specified
- Test type:
- other: No data available
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-dihydroxy-5,8-bis(4-hydroxyanilino)anthracene-9,10-dione
- Cas Number:
- 6425-07-6
- Molecular formula:
- C26H18N2O6
- IUPAC Name:
- 1,2-dihydroxy-5,8-bis(4-hydroxyanilino)anthracene-9,10-dione
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 1,2-dihydroxy-5,8-bis(4-hydroxyanilino)anthracene-9,10-dione
- Molecular formula: C26H18N2O6
- Molecular weight: 454.436 g/mole
- Smiles notation: c12c(c(Nc3ccc(O)cc3)ccc1Nc1ccc(O)cc1)C(c1ccc(c(c1C2=O)O)O)=O
-InChl:1S/C26H18N2O6/c29-15-5-1-13(2-6-15)27-18-10-11-19(28-14-3-7-16(30)8-4-14)23-22(18)24(32)17-9-12-20(31)25(33)21(17)26(23)34/h1-12,27-31,33H
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 5000 mg/kg bw (5 gm/kg)
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality observed
- Mortality:
- 50% mortality observed at 5000.0 mg/kg bw in treated rats.
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified based on CLP criteria
- Conclusions:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of 1,2-dihydroxy-5,8-bis(4-hydroxyanilino)anthracene-9,10-dione (CAS No. 6425 -07 -6) in rat by the oral route. 50% mortality was observed at 5000 mg/kg bw in treated rats. The acute oral median lethal dose (LD50) of 1,2-dihydroxy-5,8-bis(4-hydroxyanilino)anthra cene-9,10-dione in rat was observed to be 5000 mg/kg b.wt.
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of 1,2-dihydroxy-5,8-bis(4-hydroxyanilino)anthracene-9,10-dione (CAS No. 6425 -07 -6) in rat by the oral route. 50% mortality was observed at 5000 mg/kg bw in treated rats. The acute oral median lethal dose (LD50) of 1,2-dihydroxy- 5,8-bis(4-hydroxyanilino)anthra cene-9,10-dione in rat was observed to be 5000 mg/kg b.wt. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 1,2-dihydroxy-5,8-bis(4-hydroxyanilino)anthracene-9,10-dione (CAS No. 6425 -07 -6) does not exhibit acute toxicity via the oral route.
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