Registration Dossier
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EC number: 945-746-6 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 14 to 22, 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised. Validation applies, with minor restrictions due to technical inaccuracies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- adopted by the Council on 13th April 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss GLP compliance programme (inspected on November 15 and 16, 2006/ signed on March 29, 2007)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 5.05
- Temp.:
- 30 °C
- pH:
- 6
- Remarks on result:
- other:
- Remarks:
- Partition coefficient: 1.12 X 10^5
- Details on results:
- Partition coefficient of sample:
Mean log10Pow: 5.05
Partition coefficient: 1.12 x 10^5
Testing was carried out at neutral pH. - Conclusions:
- The test substance has potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow >4).
- Executive summary:
The partition coefficient of the test substance was measured under GLP according to the OECD 117/EU A8 guideline, HPLC method.The system was calibrated with 6 reference substances, and the result for the sample was interpolated from the linear regression.
Partition coefficient (log Pow) of the test substance has been determined to be 1.12 x 105, Log10Pow 5.05.
Reference
Preliminary estimate
Approximate Pow: 5.25 x 105
Log10Pow estimate: 5.72
Definitive test
Regression parameters: log Pow = 5.8593 x log k + 3.2996 (r = 0.9788)
Table 4.7/1:Partition coefficient of sample
|
RT 1 |
RT 2 |
RT 3 |
RT 4 |
RT 5 |
Mean RT |
STD
|
CV%
|
K
|
Log10K
|
Log10Pow
|
|
(min) |
(min) |
(min) |
(min) |
(min) |
(min) |
|||||
(To) Dead time |
3.97 |
3.97 |
3.97 |
3.97 |
3.97 |
3.97 |
0.00 |
0.00% |
0.00 |
- |
- |
Test item |
11.87 |
11.87 |
11.87 |
11.87 |
11.87 |
11.87 |
0.00 |
0.00% |
1.990 |
0.299 |
5.05 |
RT = Retention time
Mean RT = = Mean retention time
STD = standard deviation
CV= coefficient of variation
Mean log10Pow: 5.05
Partition coefficient: 1.12 x 105
Description of key information
The test substance has potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (>4).
It should also be taken into account for PBT assessment (logKow > 4.5).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.05
- at the temperature of:
- 30 °C
Additional information
A reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study. The result is retained as key data for purpose of CSA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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