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EC number: 289-390-3 | CAS number: 88127-84-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 February 1996 to 1 March 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- 9-[2-(2-methoxyethoxy)ethoxy]-9-[3(oxiranylmethoxy)propyl]- 2,5,8,10,13,16-hexaoxa-9-silaheptadecane was investigated for its ability to inhibit the cell multiplication of the bacteria species Pseudomonas putida according to DIN 38412 Part L 8 (March 1991) and NEN-EN-ISO 10712 (1996).the information is reported to an appropriate standard but it is not clear if the study was conducted in accordance with Good Laboratory Practice.
- Qualifier:
- according to guideline
- Guideline:
- DIN 38412-8 (Pseudomonas Zellvermehrungshemmtest)
- Deviations:
- no
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Batch number: 84246753
Expiry date: 14 August 1997 - Analytical monitoring:
- no
- Details on sampling:
- Not applicable
- Vehicle:
- no
- Details on test solutions:
- Since the test substance was soluble in water, a stock solution of 12,500 mg per litre in Milli-Q water (tap water purified by reverse osmosis and subsequently passed over activated carbon and ion-exchange cartridges (Millipore Corp., Bedford, Mass., USA)) was prepared. The solution was
thoroughly mixed to accelerate the dissolving of the test substance. No additives were used. The pH of the stock solution was 7.7.
Because of possible hydrolysis of the test substance, the test was started directly after preparation of the stock solution. - Test organisms (species):
- Pseudomonas putida
- Details on inoculum:
- Test system Pseudomonas putida.
Strain MIGULA, Berlin 33/2 (DSM 50026).
Source BGA, Berlin, Germany.
Rationale Recognized by international guidelines.
Stock cultures of the bacteria are stored in liquid nitrogen (-196°C) - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 16 h
- Remarks on exposure duration:
- Not applicable
- Post exposure observation period:
- Not applicable
- Test temperature:
- 23 + 1°C
- Nominal and measured concentrations:
- Nominal test concentrations were 313, 625, 1250, 2500, 5000 and 10000 mg/L
- Details on test conditions:
- Vessels 100 ml Erlenmeyer flasks
Incubation temperature 23 + 1°C
Incubation time
- preliminary suspension cultures 6 + 1 hours
- exposure 18 + 2 hours
Nutrient medium: 18 g of agar dissolved in water, plus 50 ml of solution I, 125 ml of solution III and 100 ml of solution IV, made up to one litre with water. - Reference substance (positive control):
- yes
- Remarks:
- 3,5 - Dichlorophenol (97 %, Aldrich).
- Key result
- Duration:
- 16 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Details on results:
- After incubation extinction values were measured and the cell multiplication inhibition for each test concentration was determined. Since no significant (significant: >10%) inhibition of cell multiplication was observed the toxicity threshold value of 9-[2-(2-methoxyethoxy)ethoxy]-9-[3(oxiranylmethoxy)propyl]- 2,5,8,10,13,16-hexaoxa-9-silaheptadecane for Pseudomonas putida was >10,000 mg/1.
- Results with reference substance (positive control):
- The EC50 value of 3,5-dichlorophenol determined for Pseudomonas putida as calculated by linear regression (Y = 5.4824 X -63.5703) was 21 mg/l. The inoculum used in the control batch was multiplied by a factor 71 within the test period. With respect to the accepted range of 10-30 mg/1 for the EC50 of the reference substance and the multiplication factor of the bacteria within the test being over 60, it was concluded that the test conditions were optimal and the results obtained were valid.
- Validity criteria fulfilled:
- yes
- Conclusions:
- No toxicity was observed. Based on the results of the test presently performed, the toxicity threshold value (EC10) was >10,000 mg/1.
- Executive summary:
9-[2-(2-methoxyethoxy)ethoxy]-9-[3(oxiranylmethoxy)propyl]- 2,5,8,10,13,16-hexaoxa-9-silaheptadecanewas investigated for its ability to inhibit the cell multiplication of the bacteria species Pseudomonas putida according to DIN 38412 Part L 8 (March 1991) and NEN-EN-ISO 10712 (1996).
Suspensions of Pseudomonas putida were exposed to concentrations of the test substance ranging from 312.5 to 10,000 mg/l. After incubation the extinction values of the bacterial cell suspensions were measured. No toxicity was observed. Based on the results of the test presently performed, the toxicity threshold value (EC10) was >10,000 mg/1. The "Bewertungszahl" (Assessment'figure or value for bacterial toxicity) is therefore < 1.9 (Bewertung wassergefährdender Stoffe, 1989).
Reference
Description of key information
9-[2-(2-methoxyethoxy)ethoxy]-9-[3(oxiranylmethoxy)propyl]- 2,5,8,10,13,16-hexaoxa-9-silaheptadecane was investigated for its ability to inhibit the cell multiplication of the bacteria species Pseudomonas putida according to DIN 38412 Part L 8 (March 1991) and NEN-EN-ISO 10712 (1996). Suspensions of Pseudomonas putida were exposed to concentrations of the test substance ranging from 312.5 to 10,000 mg/l. After incubation the extinction values of the bacterial cell suspensions were measured. No toxicity was observed. Based on the results of the test presently performed, the toxicity threshold value (EC10) was >10,000 mg/1. The "Bewertungszahl" (Assessment'figure or value for bacterial toxicity) is therefore < 1.9 (Bewertung wassergefährdender Stoffe, 1989).
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 10 000 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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