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EC number: 238-947-9 | CAS number: 14874-82-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 January 1981 – 10 February 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study apparently performed according to the method described by Noakes DN and Sanderson DM (1969) Br. J. ind. Med. Vol. 26, P. 59-64, which has some deviations from current OECD guidelines. Limited reporting, notably of test material (e.g. purity).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Noakes DN and Sanderson DM (1969) Br. J. ind. Med. Vol. 26, P. 59-64
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- The animals were prepared by closely clipping the hair “on the day of the test” (guideline states that this should be done approx. 24 hrs before the test), the animals weighed between 210 and 400 g (guideline suggests rats weighing 200-300 g be used) and
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dicarbonyl(pentane-2,4-dionato-O,O')rhodium
- EC Number:
- 238-947-9
- EC Name:
- Dicarbonyl(pentane-2,4-dionato-O,O')rhodium
- Cas Number:
- 14874-82-9
- Molecular formula:
- C7H7O4Rh
- IUPAC Name:
- Dicarbonyl(pentane-2,4-dionato-O,O')rhodium
- Details on test material:
- - Name of test material (as cited in study report): MS 371; acetylacetonatodicarbonyl rhodium (1)
- Physical state: solid
- purity: no data
- Lot/batch No.: 085108
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Tuck and Sons Ltd, Battlesbridge, Essex
- Weight at study initiation: 210-400 g
- Housing: individually during the exposure period and then in groups of up to 5 in solid floor polypropylene cages furnished with softwood sawdust
- Diet: ad libitum rat diet supplied by Nottingham University, Sutton Bonington, Near Loughborough, Leicestershire
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Air changes (per hr): a minimum of 20 air changes/hr
- Photoperiod (hrs dark / hrs light): lighting cycle of 12 hrs on and 12 hrs off with no daylight
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- arachis oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: approx. 6 x 12 cm
- Type of wrap if used: elastic adhesive bandage backed with aluminium foil
REMOVAL OF TEST SUBSTANCE
- Washing (if done): skin and surrounding hair sponged thoroughly with detergent and warm water, rinsed and dried.
- Time after start of exposure: 24 hrs
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 g/kg bw
- Concentration (if solution): 200 mg/ml
- Constant volume or concentration used: yes
- For solids, paste formed: yes - suspension
VEHICLE
- Amount(s) applied (volume or weight with unit): 10 ml/kg bw - Duration of exposure:
- 24 hrs
- Doses:
- 2 g/kg bw
- No. of animals per sex per dose:
- 5 rats/sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: ½, 1 and 4 hrs following treatment, and then once daily for 14 days
- Necropsy of survivors performed: yes, one male and one female
- Other examinations performed: clinical signs - Statistics:
- Acute dermal median lethal dose (LD50)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: No deaths reported.
- Mortality:
- There were no mortalities throughout the 14 day observation period.
- Clinical signs:
- other: All animals showed subdued activity at the ½ hr observation period. No such effects were seen after 1 hr and no other clinical effects were noted.
- Gross pathology:
- No abnormal macroscopic lesions were seen in one male and one female survivor at termination of the study. (OECD guidelines recommend all animals are necropsied.)
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a limit test, the acute percutaneous median lethal dose (LD50) of acetylacetonatodicarbonyl rhodium (I) in the rat was found to be >2000 mg/kg bw.
- Executive summary:
Acetylacetonatodicarbonyl rhodium (I) was tested for its acute dermal toxicity in rats, using a method analogous to OECD Test Guideline 402 (with some minor deviations). A group of 5 male and 5 female Sprague-Dawley rats were treated dermally (application to clipped skin under occlusion; skin was clipped on the day of the test whereas the guideline recommends that this should be done approximately 24-hr before the test) with the test item at 2 g/kg bw (in arachis oil). After 24 hours the patch was removed, the skin washed and rinsed, and the rats observed for 14 days. No deaths or signs of overt toxicity were seen in either sex and there were no abnormal macroscopic lesions in the single necropsied male and female (OECD guidelines recommend all animals are necropsied).
Based on the results of this study, acetylacetonatodicarbonyl rhodium (I) should not be classified for acute dermal toxicity according to EU CLP criteria (EU 1272/2008).
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