Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-185-5 | CAS number: 92-74-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Short report available, early study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 6 animals used, scarfied skin included
- GLP compliance:
- no
- Remarks:
- pre dates GLP
Test material
- Reference substance name:
- NaphtolAS-PH
- IUPAC Name:
- NaphtolAS-PH
- Reference substance name:
- 2'-ethoxy-3-hydroxy-2-naphthanilide
- EC Number:
- 202-185-5
- EC Name:
- 2'-ethoxy-3-hydroxy-2-naphthanilide
- Cas Number:
- 92-74-0
- Molecular formula:
- C19H17NO3
- IUPAC Name:
- N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact as well as abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6
- Details on study design:
- intact and abrade skin were examined on to neighbouring sites
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 72
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Remarks on result:
- other: no effects at all
- Irritant / corrosive response data:
- Naphtol AS PH was not irritant
- Other effects:
- none
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- Classification: not irritating
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
