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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April 14, 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised with its purity. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
inspected on 13 and 14 October 2014 / signed on 08 April 2015
Type of method:
static method
Key result
Temp.:
20 °C
Vapour pressure:
1 979 Pa
Key result
Temp.:
25 °C
Vapour pressure:
2 541 Pa

Table 4.6/2: Calculated values for 1/T and log P 

n                  

Temperature T (°C)

Pressure P (hPa)

Temperature T (K)

1/T (1/K)

log P

log Pa

1

20.0

20.0

293.15

0.00341122

3.3010

2

28.3

30.1

301.45

0.00331730

3.4786

3

36.9

44.9

310.05

0.00322529

3.6522

4

45.1

64.1

318.25

0.00314218

3.8069

5

48.6

74.2

321.75

0.00310800

3.8704

6

46.5

67.2

319.65

0.00312842

3.8274

7

36.7

44.3

309.85

0.00322737

3.6464

8

26.9

28.1

300.05

0.00333278

3.4487

9

23.7

23.9

296.85

0.00336870

3.3784

10

15.1

15.0

288.25

0.00346921

3.1761

 

Table 4.6/3: Calculated Values for vapour pressure

 

Parameter

Value

Vapour Pressure (20 °C)

1979 Pa

Vapour Pressure (25 °C)

2541 Pa

 

DISCUSSION

The vapour pressure of the test item was measured using the static method as described in EU method A.4. Ten pairs temperature/vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be estimated.

From the measured values, the vapour pressure of the test item was calculated as 1979 Pa at 20 °C and 2541 Pa at 25 °C. The values of the heating and cooling down phase showed good correspondence.

Therefore, the result of the study is considered valid.

Conclusions:
The vapour pressure of the test item was calculated as 1979 Pa at 20 °C and 2541 Pa at 25 °C.
High volatility.
Executive summary:

The vapour pressure of the test item was measured under GLP using the static method as described in EU method A.4 and OECD 104.

Ten determinations of vapour pressure were performed in a temperature range of 15.1 – 48.6 °C and the pairs of Temperature / Vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be interpolated.

The vapour pressure of the test item was calculated as 1979 Pa at 20 °C and 2541 Pa at 25 °C.

Description of key information

The vapour pressure of the test item was calculated as 1979Pa at 20°C and 2541 Pa at 25 °C (interpolation).

High volatility.

Key value for chemical safety assessment

Vapour pressure:
2 541 Pa
at the temperature of:
25 °C

Additional information

A fully reliable experimental study conducted according to a recognized OECD/EC method and under GLP, is available.

Therefore it is considered as a key study and the result is retained as key data for the purpose of CSA.