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EC number: 204-567-7 | CAS number: 122-70-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: refer below principle
- Principles of method if other than guideline:
- Naturally occurring compounds including target chemical 2-phenylethyl propanoate have been tested for molluscicidal activity against the fresh water snail, Biomphalaria alexandrina.The recommended World Health Organization bioassay procedure (WHO, 1965), was used for the evaluation of 2-phenylethyl propanoate on B. alexandrina.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): 2-phenylethyl propanoate
- Common name: Phenethyl propionate (PEP)
- Molecular formula: C11H14O2
- Molecular weight: 178.2296 g/mol
- Smiles notation: c1(CCOC(=O)CC)ccccc1
- InChl: 1S/C11H14O2/c1-2-11(12)13-9-8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3
- Substance type: Organic
- Physical state: Liquid - Analytical monitoring:
- not specified
- Details on sampling:
- Stock solutions of the tested chemicals were prepared in dimethyl sulfoxide (DMSO) to enhance the solubility.
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant):Sulfinyl bis(methane) (DMSO)
- Concentration of vehicle in test medium (stock solution and final test solution(s) or suspension(s) including control(s)):never exceeded 0.5% (v/v), and an equal amount was added to the control. - Test organisms (species):
- other aquatic mollusc: Biomphalaria alexandrina
- Details on test organisms:
- TEST ORGANISM
- Common name:Snail
- Source:Fresh water ponds at Kafr El-Dwar, Behera Governorate, Egypt
- Age of parental stock (mean and range, SD): 8 MM DIAMETER Adult(s)
- Food type: bran bait
- Amount:ad libitum
ACCLIMATION
- Acclimation period: 3 weeks - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 72 h
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 150 ml glass beakers
- Material, size, headspace, fill volume: Each chemical was mixed with Tween 20, to ensure complete solubility of the chemical in water. The mixture was added to the glass beaker filled up to 100 ml of the dechlorinated water to give the desired concentration (w/v) up to 400 μg/ml for chemical
- Type of flow-through (e.g. peristaltic or proportional diluter):
- Renewal rate of test solution (frequency/flow rate):
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates):4
- No. of vessels per control (replicates):
- No. of vessels per vehicle control (replicates):
- Biomass loading rate:
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:
- Total organic carbon:
- Particulate matter:
- Metals:
- Pesticides:
- Chlorine:
- Alkalinity:
- Ca/mg ratio:
- Conductivity:
- Salinity:
- Culture medium different from test medium:
- Intervals of water quality measurement:
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod:
- Light intensity:
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
VEHICLE CONTROL PERFORMED: yes/no
RANGE-FINDING STUDY
- Test concentrations:
- Results used to determine the conditions for the definitive study: - Reference substance (positive control):
- not specified
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 296.27 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: LC50=279.45 to 314.10 mg/L
- Reported statistics and error estimates:
- Percentage mortality was corrected using Abbott's formula (Abbott, 1925). Toxicity parameters for each treatment were computed according to the probit-analysis method by Finney (1971).
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The lethal concentration (LC50) value of phenethyl propionate in aquatic invertebrate [Biomphalaria alexandrina ] in a 72 hr study on the basis of mortality effect was found to be 296.27 mg/L.
- Executive summary:
In peer reviewed journalPakistan J. Zool., vol. 39(5), pp. 339-344, 2007 the naturally occurring compounds including target chemical 2-phenylethyl propanoate have been tested for molluscicidal activity against the fresh water snail, Biomphalaria alexandrina.The recommended World Health Organization bioassay procedure (WHO, 1965), was used for the evaluation of 2-phenylethyl propanoate on B. alexandrina.
For experimentBiomphalaria alexandrina species8mm ± 2mm diameter were collected from fresh water ponds at Kafr El-Dwar, Behera Governorate, Egypt and were maintained in glass aquaria oxygenated for one hour daily, one week before testing. The tests were performed in 150 ml glass beakers with ten adult healthy snails per assay. Each chemical was mixed with Tween 20, to ensure complete solubility of the chemical in water. The mixture was added to the glass beaker filled up to 100 ml of the dechlorinated water to give the desired concentration (w/v) up to 400 μg/ml for chemical.
The snails were exposed for 24 h to different concentrations of compounds or their mixture with PB and then transferred to dechlorinated water for another 48 h. Percentage kill were recorded after 72 h.
Percentage mortality was corrected using Abbott's formula (Abbott, 1925). Toxicity parameters for each treatment were computed according to the probit-analysis method by Finney (1971).
According to experimental result the lethal concentration (LC50) value of phenethyl propionate in aquatic invertebrate [Biomphalaria alexandrina ] in a 72 hr study on the basis of mortality effect was found to be 296.27 mg/L.
Reference
Description of key information
In peer reviewed journal Pakistan J. Zool., vol. 39(5), pp. 339-344, 2007, the naturally occurring compounds including target chemical 2-phenylethyl propanoate have been tested for molluscicidal activity against the fresh water snail, Biomphalaria alexandrina.The recommended World Health Organization bioassay procedure (WHO, 1965), was used for the evaluation of 2-phenylethyl propanoate on B. alexandrina.
For experimentBiomphalaria alexandrina species8mm ± 2mm diameter were collected from fresh water ponds at Kafr El-Dwar, Behera Governorate, Egypt and were maintained in glass aquaria oxygenated for one hour daily, one week before testing. The tests were performed in 150 ml glass beakers with ten adult healthy snails per assay. Each chemical was mixed with Tween 20, to ensure complete solubility of the chemical in water. The mixture was added to the glass beaker filled up to 100 ml of the dechlorinated water to give the desired concentration (w/v) up to 400 μg/ml for chemical.
The snails were exposed for 24 h to different concentrations of compounds or their mixture with PB and then transferred to dechlorinated water for another 48 h. Percentage kill were recorded after 72 h.
Percentage mortality was corrected using Abbott's formula (Abbott, 1925). Toxicity parameters for each treatment were computed according to the probit-analysis method by Finney (1971).
According to experimental result the lethal concentration (LC50) value of phenethyl propionate in aquatic invertebrate [Biomphalaria alexandrina ] in a 72 hr study on the basis of mortality effect was found to be 296.27 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 296.27 mg/L
Additional information
Short term toxicity to aquatic invertebrates for 2-phenylethyl propanoate (Cas no. 122-70-3) was summaries with peer reviewed experimental study and predicted data with one read across substance are summaries as follows:
First study from peer reviewed journal Pakistan journal of zoology .39(5): 339-344 for target suggest the naturally occurring compounds including target chemical 2-phenylethyl propanoate have been tested for molluscicidal activity against the fresh water snail, Biomphalaria alexandrina.The recommended World Health Organization bioassay procedure (WHO, 1965), was used for the evaluation of 2-phenylethyl propanoate on B. alexandrina. For experiment Biomphalaria alexandrina species8mm ± 2mm diameter were collected from fresh water ponds at Kafr El-Dwar, Behera Governorate, Egypt and were maintained in glass aquaria oxygenated for one hour daily, one week before testing. The tests were performed in 150 ml glass beakers with ten adult healthy snails per assay. Each chemical was mixed with Tween 20, to ensure complete solubility of the chemical in water. The mixture was added to the glass beaker filled up to 100 ml of the dechlorinated water to give the desired concentration (w/v) up to 400 μg/ml for chemical. The snails were exposed for 24 h to different concentrations of compounds or their mixture with PB and then transferred to dechlorinated water for another 48 h. Percentage kill were recorded after 72 h. Percentage mortality was corrected using Abbott's formula (Abbott, 1925). Toxicity parameters for each treatment were computed according to the probit-analysis method by Finney (1971). According to experimental result the lethal concentration (LC50) value of phenethyl propionate in aquatic invertebrate [Biomphalaria alexandrina ] in a 72 hr study on the basis of mortality effect was found to be 296.27 mg/L.
Above experimental result assist by prediction using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances. By OECD QSAR tool the short term toxicity on aquatic invertebrates was predicted for 2-phenylethyl propanoate (Cas no. 122-70-3) and EC50 value was estimated to be 112.66 mg/l for Daphnia magna for 48 hrs duration.
Both results for target assist by experimental study of read across Benzyl butyrate (Cas no. 103-37-7) (Abitec laboratory result, 2016) which indicate Short term toxicity to aquatic invertebrates was performed in Daphnia magna following the OECD guideline 202. The test was performed for 48 hrs at different concentrations as control,0,2.5,5.0,10.0,20.0,40.0 mg/l at 95 % confidence limit of 14.7 -18.7mg/l.Reference substance used was K2Cr207. 5 daphnids after breeding were used in 4 numbers of replicates of chemical.The test was performed in temperature 20°C±1°C with taking 25ml per replicate in 50ml glass vessel for 48 hrs. Calulations of EC50 was calculated using nonlinear regression by the software Prism4.0 (GraphPadSoftware,Inc.,SanDiegoCA). After experiment the EC50 value for short term toxicity to aquatic invertebrates using OECD guideline 202 was determined to be 16.6 mg/l. Based on the value the benzyl butyrate was toxic to aquatic invertebrates but as the chemical was readily biodegradable, so it can be considered that benzyl butyrate was not hazardous to aquatic invertebrates and can be considered not classified as per the CLP regulations.
Based on the target and read across chemical studies, it was considered that 2-phenylethyl propanoate (Cas no. 122-70-3) was not hazardous to aquatic invertebrates and can be considered to be not classified as chemical not exceed the aquatic classification criteria of CLP regulation.
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