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EC number: 500-005-2 | CAS number: 9003-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from saftey asessment report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- INITIAL SUBMISSION: TOXICOLOGICAL INVESTIGATION OF CP 40000 WITH COVER LETTER DATED O8OS92
- Author:
- NTRL report
- Year:
- 1 992
- Bibliographic source:
- NTRL REPORT - OTS0546159; August 5, 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- An eye irritation test was carried out in albino rabbits for test chemical to assess its irritation potential.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Formaldehyde, oligomeric reaction products with phenol
- EC Number:
- 500-005-2
- EC Name:
- Formaldehyde, oligomeric reaction products with phenol
- Cas Number:
- 9003-35-4
- Molecular formula:
- (C6H6O.CH2O)x
- IUPAC Name:
- Formaldehyde, oligomeric reaction products with phenol
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): Phenol-formaldehyde resin
- Molecular formula: C6H6O.CH2O)x-
- Molecular weight: 34.133 g/mol
- Substance type: organic
- Physical state: solid
- Smiles notation: c1(c(c(ccc1)[CH])O)O[CH]
- InChl: 1S/C8H6O2/c1-6-4-3-5-7(10-2)8(6)9/h1-5,9H
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or tissues and environmental conditions:
- No data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- Amount: 100 mL
concentration applied: 100% - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3 (Male/female)
- Details on study design:
- TEST SITE
- Area of exposure: conjunctival sac of right eye
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The eyes were rinsed with warm isotonic saline solution after 24 hours reading.
-SCORING SYSTEM: The data scored according to the method of Draize et, al.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 10.6
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Slightly irritating effects were observed.
Any other information on results incl. tables
Animal no |
Sex |
1 hour |
24 hour |
48 hour |
72 hour |
120 hour |
168 hour |
1 |
Male |
8 |
12 |
2 |
0 |
0 |
0 |
2 |
Female |
6 |
10 |
0 |
0 |
0 |
0 |
3 |
Male |
8 |
10 |
2 |
0 |
0 |
0 |
Average |
7.3 |
10.3 |
1.6 |
0.0 |
0.0 |
0.0 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The treated animals produced slight ocular reactions with the average score was 10.6 out of maximum score of 110. Hencechemical was considered to be Slightly irritating to the albino rabbits
- Executive summary:
An eye irritation test was carried out in 3 albino rabbits for test chemical to assess its irritation potential.
100ml undiluted test chemical was installed into theconjunctival sac of right eye of each rabbit.The left eye served as control.The eyes were rinsed with warm isotonic saline solution after 24 hours reading and reactions were scored up to 7 daysaccording to the method of Draize for inflammation.
The treated animals produced slight ocular reactions with the average score was 10.6 out of maximum score of 110. Hencechemical was considered to be Slightly irritating to the albino rabbits
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