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EC number: 258-649-2 | CAS number: 53585-53-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: AFNOR NF T 03-033
- Deviations:
- yes
- Remarks:
- . The following parameters were missing: the age of animals at study start, the temperature, humidity and air changes during acclimation period.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dibenzylbenzene, ar-methyl derivative
- EC Number:
- 258-649-2
- EC Name:
- Dibenzylbenzene, ar-methyl derivative
- Cas Number:
- 53585-53-8
- Molecular formula:
- C21H20
- IUPAC Name:
- dibenzylbenzene, ar-methyl derivative
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: GWEN MEUR, France
- Age at study initiation : not reported
- Weight at study initiation : 2.5 +/- 0.1 kg
- Fasting period before study: not reported
- Housing: individually in cage of 540 x 360x 315 mm
- Diet (e.g. ad libitum): 150 g of commercial granules given daily
- Water (e.g. ad libitum): filtered water ad libitum
- Acclimation period : 8 days
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark/hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 225 cm2 (15 x15 cm) on the back
- % coverage: not reported
- Type of wrap if used: adhesive
REMOVAL OF TEST SUBSTANCE
-Washing (if done): skin is wiped with a gauze pad, rinsed with tepid water and dried with paper.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1,98 ml/kg
- Concentration (if solution) : 1.01 g/mL - Duration of exposure:
- 24
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily observation and weighing on Days 1, 4, 7, 11 and 14
- Necropsy of survivors performed: dermal reactions - Statistics:
- Student's test
Results and discussion
- Preliminary study:
- No mortality was observed at any dose level.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No observed effects.
- Gross pathology:
- No abnormalities were revealed at necropsy.
- Other findings:
- CUTANEOUS FINDINGS:
In all the treated animals, a slight irritation was noted (grade 1 erythema). It disappeared on the second week. A slight cutaneous dryness was
observed between day 5 and day 10. A pelling occured between day 6 and day 11. No oedema was found at any moment.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 of the substance was found to be greater than 2000 mg/kg/bw. Therefore, no classification for acute dermal toxicity is required.
- Executive summary:
The acute dermal toxicity of Dibenzylbenzene, ar-methyl derivative was determined in rabbits in a limit test (2000 mg/kg bw) performed according the French Guideline AFNOR NF T03 -333. The mortality and general behavior of the animals were observed for a period of 14 days after the administration of the substance.
No mortality was observed at the dose-level of 2000 mg/kg. The general behavior and the bodyweight of the animals were not influenced by the treatment.
The dermal LD50 of the substance was found to be greater than 2000 mg/kg bw; therefore, no classification for acute dermal toxicity should be required.
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