Sulphoacetic acid

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Data is from computational model developed by USEPA

Qualifier:

according to guideline

Guideline:

other: estimated data

Principles of method if other than guideline:

Prediction done using ECOSAR v.1.11 model.

GLP compliance:

no

Specific details on test material used for the study:

- Name of test material (as cited in study report): Sulfoacetate (Sulphoacetic acid)
- Molecular formula (if other than submission substance): C2H4O5S
- Molecular weight (if other than submission substance): 140.115 g/mol
- Substance type: Organic
- Physical state: solid
- Purity: no data
- Impurities (identity and concentrations): no data

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: fish

Test type:

static

Water media type:

saltwater

Limit test:

no

Total exposure duration:

96 h

Test temperature:

25 Deg.C

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

547 000 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: ECOSAR Class: Neutral Organics

Conclusions:

Based on the EPI Suite ECOSAR version 1.10 prediction model, the 96 hours LC50 was estimated to be 547000 mg/l on Fish for Sulphoacetic acid (CAS no.123-43-3) on the basis of mortality effects.

Executive summary:

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for Sulphoacetic acid (CAS no.123-43-3) the effects observed in a static saltwater system. The lethal concentration LC50 value for the Sulphoacetic acid (CAS no.123-43-3) was estimated to be 547000 mg/l for fish for 96 hr exposure duration. Based on this lethal value it can be concluded that the Sulphoacetic acid (CAS no.123-43-3) is likely to be non toxic to aquatic environment and thus it can be considered as not classified as per the CLP classification criteria.

Description of key information

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for Sulphoacetic acid (CAS no.123-43-3) the effects observed in a static freshwater system. The lethal concentration LC50 value for the Sulphoacetic acid (CAS no.123-43-3) was estimated to be 442000 mg/l for fish for 96 hr exposure duration. Based on this lethal value it can be concluded that the Sulphoacetic acid (CAS no.123-43-3) is likely to be non toxic to aquatic environment and thus it can be considered as not classified as per the CLP classification criteria.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

442 000 mg/L

Additional information

Three studies of predicted data from validated tools and authorative database for toxicity to aquatic algae endpoint of test chemical Sulphoacetic acid (Cas no. 123-43-1) were summarised as follows:

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for Sulphoacetic acid (CAS no.123-43-3) the effects observed in a static freshwater system. The lethal concentration LC50 value for the Sulphoacetic acid (CAS no.123-43-3) was estimated to be 442000 mg/l for fish for 96 hr exposure duration.

Another prediction done by Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for Sulphoacetic acid (CAS no.123-43-3) the effects observed in a static saltwater system. The lethal concentration LC50 value for the Sulphoacetic acid (CAS no.123-43-3) was estimated to be 547000 mg/l for fish for 96 hr exposure duration.

Using Battery algorithm model of Danish QSAR Short-term toxicity to Fathead minnow for Sulphoacetic acid was estimated to be LC50 = 6758.767mg/L at 96 hrs.

Thus based on the effect concentrations which is in the range 6758.767 mg/l to 547000 mg/l give the conclusion that test substance Sulphoacetic acid (Cas no. 123-43-was likely to be non-toxic to fish at environmentally relevant concentrations and can be considered to be not classified as per the CLP classification criteria.