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EC number: 217-978-1 | CAS number: 2028-63-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-06-08 to 1988-06-29
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- But-3-yn-2-ol
- EC Number:
- 217-978-1
- EC Name:
- But-3-yn-2-ol
- Cas Number:
- 2028-63-9
- Molecular formula:
- C4H6O
- IUPAC Name:
- but-3-yn-2-ol
Constituent 1
- Specific details on test material used for the study:
- - Color: yellow
- Form: liquid
- Storage: at room temperature
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, 7950 Biberach, Germany
- Age at study initiation: 8 - 9 weeks
- Weight at study initiation: males 260 +/- 8.3 g; females 189 +/- 8.0 g
- Housing: 5 animals per cage; wire cages, type DIII (Company Becker); no bedding
- Diet: ad libitum; KLIBA laboratory diet rat/mouse A 343 10-mm pellets (Klingentalmuehle AG, Kaiseraugst, Switzerland)
- Water: ad libitum; tap water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Air changes (per hr): AC controlled
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Whole-body inhalation system
- Exposure chamber volume: V = 200 L
- Method of holding animals in test chamber: single; in wire cages which were located in a glass-steel inhalation chamber
- Source and rate of air: air was supplied by central AC; Volume of air was 3000 L/h
- Method of conditioning air: central air conditioning
- System of generating particulates/aerosols: continuous infusion pump INFU 362 (INDIGEL/Switzerland) and a glass evaporator with thermostat
- Temperature, humidity, pressure in air chamber: temp: 19-25°C in the exposure apparatus; underpressure was adjusted to 100 L/h in the treatment chamber
TEST ATMOSPHERE
- Brief description of analytical method used: once per hour samples were taken (one per treatment group); the vapour was collected into Propanol-2; Analysis was done with a gas chromatograph (GC HP 584ß A, Hewlett Packard)
- Samples taken from breathing zone: yes
VEHICLE
- Composition of vehicle: air
- Concentration of test material in vehicle: Concentration was determined through substance use and air volume used; and in samples via mass determination and sample volume (mg/L)
CLASS METHOD
- Rationale for the selection of the starting concentration: The concentration 3.33 mg/L was selected on the basis of the information available on the toxicity of the test substance. The remaining concentrations were selected in such a way that it was possible to determine an LC50. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 0.53, 2.09, 3.33 mg/L (nominal)
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- After the exposure period, the surviving animals were observed for 14 days.
The body weight of the animals was checked before the beginning of the test, after 7 days and at the end of the observation period. Clinical findings were generally recorded several times during exposure and at least once each workday during the post-exposure observation period. A check for mortalities was made daily.
At the end of the 14-day observation period, the surviving animals were sacrificed with CO2 and were subjected to a gross-pathological examination like all other animals which had died before. - Statistics:
- Statistical analysis of concentration-effect ratio was done with FORTRAN-programm AKPROZ.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.53 - < 2.09 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- 0.53 mg/L: no deaths; 2.09 and 3.33 mg/L: 10/10
- Clinical signs:
- other: During exposure: irregular, delayed up to lengthy breathing, paleness of ear and extremities, severe apathy, abdominal position, crouch position, ruffled fur, watery nasal secretion, salivation, lachrymation After exposure: lengthy and delayed breathing,
- Body weight:
- Body weight development was recorded for the surviving animals (0.53 mg/L). Females showed no differences to historical controls. Males had a shlight delay during the 2. week of observation.
- Gross pathology:
- Animals that died: acute congestive hyperemia; lung: acute emphysema - moderate (9 x)
Sacrificed animals: organs: nothing abnormal detected - Other findings:
- No other findings were observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
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