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EC number: 246-426-2 | CAS number: 24717-85-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 Sep - 25 Oct 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test)
- Version / remarks:
- 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.29 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test))
- Version / remarks:
- 2014
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss federal office of public health consumer protection directorate notification authority for chemicals
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: activated sludge of the local waste water treatment plant, ARA Birs, Birsfelden, Switzerland
- Storage conditions: aerated with CO2-free air at room temperature
- Storage length: holding period of two days prior to use
- Preparation of inoculum for exposure: washed three times by centrifugation, decantation of the supernatant liquid phase and resuspension of the solid material in tap water and finally in mineral medium
- Concentration of sludge: 4 mg dry material per liter
- Initial cell/biomass concentration: 4 mg dry material per liter
- Water filtered: no - Duration of test (contact time):
- 28 d
- Initial conc.:
- 26.4 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 mg/L
- Based on:
- TOC
- Parameter followed for biodegradation estimation:
- inorg. C analysis
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to the guidelines; pH adjusted to 7.7 to 7.4
- Test temperature: 20 °C
- pH: 6.8 (test item bottle), 7.3 (inoculum control bottle)
- Continuous darkness: yes
TEST SYSTEM
- Test vessel: 160 mL-Wheaton glass serum bottles (total volume), sealed with aluminium crimp caps with Teflon lined chlorobutyl septa
- Culturing condition: on an orbital shaker, shaking rate of 200 rpm in a temperature-controlled environment
- Number of culture flasks/concentration: 30 bottles (test item, inoculum control), 20 bottles (reference control), 12 vessels (toxicity control), at least three bottles were measured on each sampling timepoint
- Method used to create aerobic conditions: sealed bottles with a headspace of air
- Measuring equipment: inorganic carbon (IC) measured with TOC infrared gas analyzer, equipped with an automatic sampler (i.e. vario TOC cube from Elementar Analysensysteme GmbH, Germany)
- Test item application: injected into sealed bottles containing the inoculated mineral medium using a high precision syringe
SAMPLING
- Sampling frequency: Test item and inoculum control: Exposure Day 0, 2, 5, 7, 10, 14, 21 and 28; Procedure control: Exposure Day 0, 2, 7, 14 and 28; Toxicity control: Exposure Day 0, 14 and 28;
- Sampling method: 1 mL of 7M NaOH solution injected in each bottle and shaken for 1 h at the test conditions; test and control bottles were removed from the shaker and allowed to settle; suitable volumes of the liquid phase were withdrawn and subjected to IC analysis; 3 bottles were measured on each sampling occasion and 5 bottles from each series (except the toxicity control) were analyzed at the end of the test
CONTROL AND BLANK SYSTEM
- Inoculum blank: 3 replicates per sampling time (5 replicates at test end)
- Toxicity control: 26.4 mg/L test item and 26.1 mg/L reference item (corresponding to 20 mg TOC/L and 19.2 mg TOC/L); 3 replicates per sampling time (5 replicates at test end)
- Reference control: was tested with 26.1 mg/L 1-octanol (corresponding to 19.2 mg TOC/L); 3 replicates per sampling time (5 replicates at test end)
- Reference substance:
- other: 1-octanol
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 89
- Sampling time:
- 28 d
- Remarks on result:
- other: 95 % confidence interval of ± 1.0 %
- Details on results:
- - pass level (10% degr.) reached after 14 days
- 10-day time window was fulfilled - Results with reference substance:
- Functional control (1-Octanol): 86% degradation after 14 days
Toxicity control: 100% degradation within 14 days - Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The substance was found to be readily biodegradable under the test conditions, with a mean percentage biodegradation of 89% at the end of the 28-day exposure period. The pass level for ready biodegradability (IC production of at least 60% of ThIC in a 10-day window within the 28-day test period) was reached on exposure day 14 (62%).
Reference
Table 1: Percentage Biodegradation of the Test Item and the Reference Item 1-Octanol during the Incubation Period
Time (days) |
% Degradation |
|||||||||||
Test item |
Reference item |
|||||||||||
Replicate No. |
Replicate No. |
|||||||||||
1 |
2 |
3 |
4 |
5 |
mean |
1 |
2 |
3 |
4 |
5 |
mean |
|
0 |
0.7 |
1.2 |
0.7 |
-- |
-- |
0.8 |
0.7 |
1.7 |
0.7 |
-- |
-- |
1.0 |
2 |
0.0 |
0.5 |
0.0 |
-- |
-- |
0.2 |
31.7 |
30.1 |
29.1 |
-- |
-- |
30.3 |
5 |
13.7 |
12.7 |
11.7 |
-- |
-- |
12.7 |
-- |
-- |
-- |
-- |
-- |
n.a. |
7 |
33.6 |
46.1 |
31.6 |
-- |
-- |
37.1 |
71.2 |
67.6 |
72.2 |
-- |
-- |
70.3 |
10 |
59.5 |
50.4 |
57.5 |
-- |
-- |
55.8 |
-- |
-- |
-- |
-- |
-- |
n.a. |
14 |
64.3 |
61.3 |
60.8 |
-- |
-- |
62.1 |
84.9 |
86.4 |
85.9 |
-- |
-- |
85.7 |
21 |
94.0 |
96.0 |
94.0 |
-- |
-- |
94.7 |
-- |
-- |
-- |
-- |
-- |
n.a. |
28 |
88.1 |
88.6 |
90.6 |
88.1 |
89.6 |
89.0 |
98.1 |
97.1 |
98.1 |
94.5 |
92.4 |
96.0 |
(table continued below)
Time(days) |
%Degradation |
|||
Toxicity control1 |
||||
Replicate No. |
||||
1 |
2 |
3 |
mean |
|
0 |
1.7 |
0.7 |
1.2 |
1.2 |
2 |
-- |
-- |
-- |
n.a. |
5 |
-- |
-- |
-- |
n.a. |
7 |
-- |
-- |
-- |
n.a. |
10 |
-- |
-- |
-- |
n.a. |
14 |
95.3 |
103.1 |
100.5 |
99.6 |
21 |
-- |
-- |
-- |
n.a. |
28 |
116.3 |
106.4 |
107.5 |
110.1 |
1: Based on the added TOC from the reference item only.
--: No samples taken.
n.a.: Not applicable
Description of key information
Readily biodegradable (89% within 28 d, OECD 310)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
One experimental study is available investigating the biodegradability of the substance. The study was performed according to the OECD 310 (GLP). Non-adapted, domestic activated sludge from a sewage treatment plant was used as inoculum. After 28 d a mean degradation of 89% was recorded based on CO2-evolution (IC production increased from Day 2 until Day 21). Thus, the substance is considered to be readily biodegradable according to the OECD criteria. A toxicity control containing both, reference substance and test substance, did not indicate inhibitory effects to the inoculum (100% degradation after 14 d). All validity criteria of the study were met.
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