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EC number: 206-076-3 | CAS number: 299-29-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: PARCOM method 1995
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Details on sampling:
- Photoperiod: Ambient laboratory lighting with a daily 10 hour photoperiod.
Aeration: Air bubbled directly into test media. - Details on test solutions:
- Dilution media: Artificial seawater (Coral Ree[ Kent Sea Salt, Red Sea Fish Pharm).
- Test organisms (species):
- other: Scophthalmus mamimus (Juvenile turbot)
- Details on test organisms:
- Juvenile turbot were received on 19 October 2000 free of malformations and in good health and assigned a batch number of SM00009.
Supplied by Mannin Sea Farms, Derbyhaven, Isle of Man.
Animals were fed and maintained as detailed in STL Runcorn SOP 1.16. Stock juvenile turbot were held in artificial seawater (STL Runcorn SOP 111.12)
maintained at 15 ± 2°C by a chiller unit and aerated via air diffusers attached to the laboratory air supply system. Feeding was stopped when juvenile turbot were transferred to test tanks 24 hours before the start of the tests. - Test type:
- semi-static
- Water media type:
- saltwater
- Total exposure duration:
- 96 h
- Post exposure observation period:
- Animals were observed twice every 24 hours. Numbers of mortalities and animals exhibiting abnormal behaviour were recorded. At the end of the test a sample of juvenile turbot was weighed and measured. The mean values and standard deviations were calculated and recorded.
- Hardness:
- No data
- Test temperature:
- Ranged from 13.3-15.1 C
- pH:
- Mean ranged from 6.92 to 8.16
- Dissolved oxygen:
- Mean Ranged from 79.7 to 95.4 %
- Salinity:
- Ranged from 31.5-33.0
- Nominal and measured concentrations:
- Nominal concentrations of the test solution of 100.0, 177.8, 316.2, 562.3 and 1000.0 mg/L were prepared in artificial seawater
- Details on test conditions:
- Single replicates of 10 litres at each test concentration and control media were prepared. Seven animals were added to each test vessel and exposures conducted under semi-static conditions with replacement of media every 24 hours. Test duration was 96 hours at a nominal temperature of 15 ± 2°C.
Exposures were conducted between 6 November and 10 November 2000. - Reference substance (positive control):
- yes
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/L
- Basis for effect:
- mortality (fish)
- Details on results:
- All animals in the control vessels survived the 96 hour test period. After 96 hours exposure to the test material, the LC50 was determined to be > 1000.0 mg/L. The the LC50 values after 24, 48 and 72 hours were also determined to be > 1000.0 mg/L in this study. The concentration of test material producing No Observable Effect, (NOEC). was determined to be 1000.0 mg/L after 96 hours. The concentration of test material producing the Lowest Observed Effect, (LOEC), could not be determined. None of the concentrations tested produced 100% mortality in this study.
- Reported statistics and error estimates:
- The mortality data calculated at each observation period is usually proccessed using the statistical computer programme Toxcalc, supplied by Tidepool Scientific (STL Runcorn SOP V .1 ). Toxcalc is used to derive the median effect concentration (LC50) which kills (immobilises) 50% of the animals exposed to the test material, together with 95% fiducial limits and a No Observed Effect Concentration (NOEC). However, the data was deemed unsuitable for such analysis in this case.
- Sublethal observations / clinical signs:
After 96 hours exposure to concentrations of the test substance, the LC50 was determined to be > 1000.0 mg/L in this study. None of the concentrations tested produced 100% mortality in this study.
Throughout the study tanks at concentrations of 316.2, 562.3, and 1000.0 mg/L were observed to have pH values lower than the acceptable control limits. The pH for these concentrations was not altered to within acceptable control tolerance levels. This was in compliance with the test guidelines, which recommend that the test should be carried out without adjustment of the pH. The pH values did not effect the overall test result, as the LC50 was greater than the higher concentration tested.
It was also observed that the DO values were lower than the acceptable control limits in new tanks at concentrations of 316.2, 562.3 and 1000.0 mg/L. However, new airlines were introduced before the addition or the test organisms.
- Conclusions:
- The 96 hour LC50 value was determined to be > 1000.0 mg/L for iron gluconate to juvenile turbot. The NOEC was 1000 mg/L for exposures of iron gluconate to juvenile turbot.
Iron Gluconate is classified as non-hazardous for this end point - Executive summary:
In study STL001005, a sample of iron gluconate was assessed for its potential toxicity to juvenile turbot in a semi-static test over 96 hours in accordance with the PARCOM method 1995, OECD guideline 203 and as detailed in STL Runcorn SOP ITT .6. Test concentrations were prepared over the range of 100.0 mg/L to 1000.0 mg/L. Juvenile turbot were exposed to the test concentrations in order to determine the concentration which killed 50% of the test organisms over 96 hours (LC50). From this study the 96 hour LC50 value was determined to be > 1000.0 mg/L. The 24, 48 and 72 hour values were also determined to be > l000 mg/L from this study.
Iron Gluconate is classified as non-hazardous for this end point
Reference
Description of key information
A sample of iron gluconate was assessed for its potential toxicity to juvenile turbot in a semi-static test over 96 hours in accordance with the PARCOM method 1995, OECD guideline 203 and as detailed in STL Runcorn SOP ITT .6. Test concentrations were prepared over the range of 100.0 mg/L to 1000.0 mg/L. Juvenile turbot were exposed to the test concentrations in order to determine the concentration which killed 5O% of the test organisms over 96 hours (LC50). From this study the 96 hour LC50 value was determined to be > 1000.0 mg/L. The 24, 48 and 72 hour values were also determined to be > 1000 mg/L from this study.
Iron Gluconate is classified as non-hazardous for this end point
Key value for chemical safety assessment
Marine water fish
Marine water fish
- Effect concentration:
- 1 000 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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