Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 944-610-3 | CAS number: 286472-48-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin corrosion (OECD TG 431): non-corrosive
Skin irritation (OECD TG 439): Causes Skin Irritation - Category 2
Skin irritation in rabbit (OECD TG 404): moderate irritation -- Category 3 uner GHS, no classification warratned under CLP
Eye irritation in BCOP (OECD TG 437): not requireing classification
Eye irritation in rabbit (OECD TG 405): no classification warranted
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation:
In vitro tests
The skin irritancy of the test substance, FRET 05 -0293 was determined according to OECD Guideline 439 using the EPISKIN™ Reconstructed Human Epidermis Model. The relative mean viability of the test item treated tissues was 40.6 % after a 15-Minute exposure period and 42 hours post-exposure incubation period. This result shows that the substance is a skin irritant, according to EU CLP criteria.
The skin corrosivity of the test substance was determined according to OECD Guideline 431 using the EpiDerm™ Reconstructed Human Epidermis Model. The relative mean viability of 3 and 60 minute exposures were above 50 and 15% respectively in relation to the control. Therefore the substance is not corrosive to skin, according to EU CLP criteria.
In vivo tests
The study was performed to assess the irritancy potential of the test item to the skin of the New Zealand White rabbit, according to OECD TG 404.
A single 4 Hour, semi occluded application of the test item to the intact skin of two rabbits produced well-defined erythema and slight edema. Other skin reactions noted were loss of skin elasticity, crust formation and slight desquamation. No corrosive effects were noted.
The test item produced a primary irritation index of 4.0 and was classified as a moderate irritant to rabbit skin according to the Draize classification scheme.
The test item meets the criteria for classification as a Mild irritant (Category 3) according to the Globally Harmonized System of Classification and Labelling of Chemicals.
The test item does not meet the criteria for classification according to Regulation (EC) No. 1272/2008, relating to the Classification, Labelling and Packaging of Substances and Mixtures.
Eye irritation:
In vitro test
The test item FRET 05 -0293 was tested for eye irritation or serious eye damagaccording to OECD Test Guideline 437 (Bovine Corneal Opacity and Permeability Assay". The result indicated
the test item as "No category" thus not requiring classification to UN GHS or EU CLP.
In vivo test:
The study was performed conducted according to OECD Test Guideline 405 to assess the irritancy potential of the test item, FRET 05-0293, to the eye of the New Zealand White rabbit.
A single application of the test item to the non-irrigated eye of two rabbits produced moderate conjunctival irritation. One treated eye appeared normal at the 72-Hour observation and the other treated eye appeared normal at the 7-Day observation.
The test item produced a maximum group mean score of 9.0 and was classified as a mild irritant (Class 4 on a 1 to 8 scale) to the rabbit eye according to a modified Kay and Calandraclassification system.
The test item does not meet the criteria for classification according to theGlobally Harmonized Systemof Classification and Labelling of Chemicals or to Regulation (EC) No. 1272/2008, relating to the Classification, Labelling and Packaging of Substances and Mixtures.
Justification for selection of skin adn eye irritation / corrosion
endpoint:
The results of the studies are reliable and adequate for covering
the endpoint.
Effects on skin irritation/corrosion:moderate irritating category
3 under GHS, no need classification under CLP.
Effects on eye irritation/corrosion: no need classification under CLP.
Justification for classification or non-classification
Based on the results in the skin and eye irritation/corrosive tests the substance does not need classification according to EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.