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EC number: 253-197-2 | CAS number: 36768-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study was performed prior to OECD guideline and GLP but follows principles thereof.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1981
- GLP compliance:
- no
- Remarks:
- no GLP implemented at that time
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2,6,6-tetramethyl-4-piperidylamine
- EC Number:
- 253-197-2
- EC Name:
- 2,2,6,6-tetramethyl-4-piperidylamine
- Cas Number:
- 36768-62-4
- Molecular formula:
- C9H20N2
- IUPAC Name:
- 2,2,6,6-tetramethylpiperidin-4-amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: W. Gassner, Sulzfeld, Germany
- Weight at study initiation: males: 160-210 g, females 125-170 g
- Fasting period before study: 16 hours
- Housing: 5 per cage
- Diet:. ad libitum
- Water: ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-23°C
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
-
MAXIMUM DOSE VOLUME APPLIED: constantly 10 ml/kg bw
- Doses:
- 1; 1.21; 1.47; 1.78 ml/kg bw (corresponding to 893, 1080, 1310, 1590 mg/kg bw)
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
body weight: once day of application, day 7 and day 15,
clinical signs: on application day several times, thereafter once daily.
- Necropsy of survivors performed: yes - Statistics:
- Probit analysis according to FINNEY
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 000 mg/kg bw
- 95% CL:
- 820 - 1 089
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1.106 mL/kg bw
- 95% CL:
- 0.92 - 1.22
- Mortality:
- control: no mortality ocurred
Dose group 1: 3 of 5 females died on days 3-7
Dose group 2: one male and three females died within 6-24 hours after exposure, further one male and two females died on day 2 after application
Dose group 3: one male and three females died within 6-24 hours after exposure, further two females died on day 2 after application, three males died on day 3-7 after application.
Dose group 4: 4 males and 5 females died within 6-24 hours after exposure, further one male died on day 2 after application. - Clinical signs:
- other: Clinically non-characteristic signs of extreme discomfort and suffering (like piloerection, decrease of motility, paleness of extremities)
- Gross pathology:
- congestion of spleen and liver, corrosions in the gastro-intestinal tract, destruction of the intestinal mucosa.
- Other findings:
- Findings are consistent with tissue colliquations caused by strongly alkaline substances.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Under present conditions, a single adminitration of the test item revealed a LD50 of 1000 mg/kg bw (95-% confidence range: 830 - 1100 mg/kg.)
Clinically non-characteristic signs of extreme discomfort and suffering. Macroscopic pathological findings were congestion of spleen and liver, corrosions in the gastro-intestinal tract, destruction of the intestinal mucosa.
Findings are consistent with tissue colliquations caused by strongly alkaline substances.
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