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EC number: 205-711-1 | CAS number: 148-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin sensitisation, patch test (key, RL2): sensitising
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Sensitisation
No skin sensitisation studies in animals are available to evaluate the skin sensitizing properties of quinolin-8-ol (CAS 148-24-3). However, relevant information in humans is available that allow a final assessment of skin sensitising properties induced by quinolin-8-ol.
Skin sensitising properties of quinolin-8-ol (CAS 148-24-3) were determined in a human Patch test by topical application of the test substance (Pevny and Schellenberger, 1971). Three Patch tests were conducted with 100 or 127 patients. A positive sensitisation response was observed in all three tests. The indices of sensitivity (percentage of positive responses) were 4.7%, 8% and 6% in all 3 studies, respectively. Thus, quinolin-8-ol is considered to be an allergen in humans.
Furthermore, patients showed signs of contact allergy to quinolin-8-ol and to 8-hydroxyquinoline sulphate during dermatological therapies. In detail, in an epidermal test series for the determination of contact eczema caused by drugs within a period of six years, hypersensitivity to 8-hydroxyquinoline was observed in 3/450 patients indicating that quinolin-8-ol is a weak contact allergen. Furthermore, 8-hydroxyquinoline sulphate showed a positive response in one subject at concentrations above 0.01% and was considered as strong sensitiser (as cited in RAC opinion (Rothe, 1978; Metzner, 1987).
Overall conclusion
Based on the available data, human data provide evidence that quinolin-8-ol exhibits skin sensitisng properties by skin contact in a substantial number of people. Thus, quinolin-8-ol is considered as skin sensitizer. Due to limited information, sub-categorisation according to CLP criteria is not possible.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data on skin sensitization induced by quinolin-8-ol (CAS 148 -24 -3) meet the criteria for classification as Skin sens 1, H317 according to Regulation (EC) 1272/2008. Due to limited information, sub-categorisation according to CLP criteria is not possible.
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