Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-358-1 | CAS number: 524-38-9
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment
From BCFBAF Program (v3.00) model of EPI suite and PBT profiler the estimated bio concentration factor (BCF) for 2-hydroxy-1H-isoindole-1,3(2H)-dione is 3.2 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that 2-hydroxy-1H-isoindole-1,3(2H)-dione is not expected to bio accumulate in the aquatic environment.
Additional information
Bioaccumulation: aquatic / sediment
Four studies including all predicted data from validated models and experimental data from authorative database for bioaccumulation (BCF) endpoint of target chemical 2-hydroxy-1H-isoindole-1,3(2H)-dione (Cas no. 524-38-9) with relevant read across which is structurally similar to target were summarized as follows:
First prediction done using BCFBAF (v3.00) model and PBT profiler which indicate the estimated bio concentration factor (BCF) for 2-hydroxy-1H-isoindole-1,3(2H)-dione is 3.2 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that the substance is not expected to bio accumulate in the aquatic environment.
Above prediction is supported by data from Scifinder database which suggest the Bioconcentration factor (BCF) for target chemical 2-hydroxy-1H-isoindole-1,3(2H)-dione to be 6.32 to 6.37 at pH range 1-4, 5.90 at pH 5, 3.55 at pH 6, 1.0 at pH range 7-10 and temperature 25 deg.C.Based on the BCF concentration at all range of pH it is concluded that the test chemical 2-hydroxy-1H-isoindole-1,3(2H)-dione is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
And Chemspider - ACD/PhysChem Suite prediction model indicate the Bioconcentration factor (BCF) for target chemical 2-hydroxy-1H-isoindole-1,3(2H)-dione to be 1.54 at pH 5.5 and 1 at pH 7.4 at temperature 25 deg.C. Based on the BCF concentration at two different pH concluded that the test chemical 2-hydroxy-1H-isoindole-1,3(2H)-dione is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
Above all results for target are further supported by experimental data of read across chemical Phthalimide (Cas no. 85-41-6) wherein an estimated BCF value of 4.4 was calculated for phthalimide, using an experimental log Kow of 1.15 and a recommended regression derived equation. This BCF value suggests that bioconcentration in aquatic organisms will not be an important fate process.(HSDB database by US EPA;2017)
Thus based on all available studies for bioaccumulation endpoint concluded that the test substance 2-hydroxy-1H-isoindole-1,3(2H)-dione (Cas no. 524-38-9) is expected to be non Bioaccumulative in aquatic environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
