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EC number: 238-744-5 | CAS number: 14694-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 22-May 6 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was carried out in accordance with the relevant OECD guideline for 1988, the year in which it was performed, and was GLP compliant.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tris(triphenylphosphine)rhodium (I) chloride
- EC Number:
- 238-744-5
- EC Name:
- Tris(triphenylphosphine)rhodium (I) chloride
- Cas Number:
- 14694-95-2
- Molecular formula:
- C54H45ClP3Rh
- IUPAC Name:
- tris(triphenylphosphine)rhodium (I) chloride
- Details on test material:
- - Name of test material (as cited in study report): Chlorotris-(triphenylphosphine)-rhodium(I)
- Molecular formula (if other than submission substance):
- Molecular weight (if other than submission substance):
- Smiles notation (if other than submission substance):
- InChl (if other than submission substance):
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type:
- Physical state: red powder
- Analytical purity: 11% Rh
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
- Isomers composition:
- Purity test date:
- Lot/batch No.: 6549
- Expiration date of the lot/batch:
- Radiochemical purity (if radiolabelling):
- Specific activity (if radiolabelling):
- Locations of the label (if radiolabelling):
- Expiration date of radiochemical substance (if radiolabelling):
- Stability under test conditions: According to information from the sponsor, decomposition need to be expected throughout the experimental period [sic].
- Storage condition of test material: room temperature
- Other:pH value: neutral
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar Bor: WISW (SPFTNO)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Winkelmann Versuchstierzucht GmbH & Co. KG., D-4799 Borchen
- Age at study initiation: Males, 9 weeks; Females, 10 weeks
- Weight at study initiation: Males, 180-226 g; Females, 147-175 g
- Fasting period before study:16 hrs before treatment
- Housing: Macrolon cages, type II
- Diet (e.g. ad libitum): standard diet ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.5-21.5ºC
- Humidity (%): 35-65%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 06:00-18:00 hrs artificial lighting; 18:00-06:00 hrs natural light-dark-rhythm
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous Tylose suspension (1%)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle:250 mg/ml
- Amount of vehicle (if gavage): 20 ml/kg bw
- Justification for choice of vehicle: test substance not soluble in water
- Lot/batch no. (if required): no data (Tylose supplied by Hoeschst AG, D-6000 Frankfurt)
- Purity: no data
MAXIMUM DOSE VOLUME APPLIED: 20 ml/kg bw
DOSAGE PREPARATION (if unusual):
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 rats/sex/dose
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were continuously observed for first 4-8 hrs after administration and then twice daily. Bodyweights were recorded at the beginning and at 7 and 14 days after administration of test substance.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight- Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No deaths occurred during the 14-day observation period after 5 male and 5 female rats were treated with 5000 mg/kg bw test substance.
- Clinical signs:
- No systemic toxic effects were observed.
- Body weight:
- Body weights for the treated animals were reported for days 0, 7 and 14 of the study. Both male and female animals showed increased bodyweights at day 7 and again at day 14. However, bodyweight data for vehicle control animals or historical laboratory data are not provided. The study authors do not comment on bodyweight increases.
- Gross pathology:
- No abnormalities were detected on gross necropsy at the end of the 14-day observation period. Macroscopic examination included external appearance, body orifices, body cavities (thoracic and abdominal) and their contents).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 for chlorotris-(triphenylphosphine)-rhodium(I) was established to be above 5000 mg/kg bw in rats.
- Executive summary:
The acute oral toxicity of chlorotris-(triphenylphosphine)-rhodium(I) was investigated in an OECD Test Guideline 401 study, conducted according to GLP. Test substance was administered by oral stomach tube to Wistar Bor rats (5/sex) at a limit dose of 5000 mg/kg bw (in aqueous Tylose suspension). Animals were observed daily and weighed weekly. No mortality was observed over the 14-day observation period and no abnormalities were seen at macroscopic post mortem examination. The acute oral LD50 value for chlorotris-(triphenylphosphine)-rhodium(I) in rats was therefore established to be above 5000 mg/kg bw.
Based on the results of this study, no classification is required for acute oral toxicity according to EU CLP criteria (EC 1272/2008).
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