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Diss Factsheets
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EC number: 201-678-2 | CAS number: 86-52-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity oral in rat was reported as LD50 890 mg/kg.
Acute toxicity dermal in rabbit was reported as LD50 2000 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: collection of data, but record lacks methodological details
- Principles of method if other than guideline:
- no data on guideline, Study period lies before the acceptance of guidelines
- GLP compliance:
- not specified
- Remarks:
- Data retrieval was performed in 2016 by using RTECS. Toxicity values without further details are given. The cited reference lacks information on GLP compliance and year of study.
- Test type:
- other: no data, but probable standard acute method
- Specific details on test material used for the study:
- no specific details given
- Species:
- rat
- Route of administration:
- oral: unspecified
- Key result
- Dose descriptor:
- LD50
- Effect level:
- ca. 890 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
Acute toxicity oral in rat was reported in RTECS as LD50 890 mg/kg,
Toxicity data reference: Industrial Hygiene Foundation of America, Chemical and Toxicilogical Series, Bulletin (Pittburgh, Pa) 1947 -69
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 890 mg/kg bw
- Quality of whole database:
- Study period lay before the acceptance of guidelines, but reliable authors
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: collection of data, but record lacks methodological details
- Principles of method if other than guideline:
- Probably standard dermal toxicity study
- GLP compliance:
- not specified
- Remarks:
- Data retrieval was performed in 2016 by using RTECS. Toxicity values without further details are given. The cited reference lacks information on GLP compliance and year of study.
- Test type:
- standard acute method
- Specific details on test material used for the study:
- no data given
- Species:
- rabbit
- Key result
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 000 mg/kg bw
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
Acute toxicity dermal in rabbit was reported as LD50 2000 mg/kg.
Toxicity data reference: Industrial Hygiene Foundation of America, Chemical and Toxicilogical Series, Bulletin (Pittburgh, Pa) 1947
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: collection of data, but record lacks methodological details
- Specific details on test material used for the study:
- 98,9 - 100,2 %
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Type of coverage:
- not specified
- Doses:
- 0, 200, 1000, 5000 mg/kg bw.
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- no
- Interpretation of results:
- Category 5 based on GHS criteria
- Executive summary:
Acute toxicity dermal in rat was reported in RTECS as LD50 >5000 mg/kg.
Data from Kiso to Rinsho Clinical Report (Yubunsha Co., Ltd., 1 -5. Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.