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EC number: 234-324-0 | CAS number: 11099-06-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 92/69/EEC, C.1
- Principles of method if other than guideline:
- Short term evaluation of test material on Brachydanio rerio was evaluated for 96 h
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Remarks:
- Analytical assessment of the test substance concentrations was performed using carbon determination on a TOC-500 Infrared Analyzer
- Details on test solutions:
- The hard-to-dissolve test substance was added to the synthetic fresh water to provide a concentration of 1 g/l, and was stirred for 18 hours. Then the solution was
filtered and the carbon content was determined. A single test concentration of 119 mg/l was measured for this study - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebra fish
ACCLIMATION
- Acclimation period: 14 days
-Weight: 0.4 g
FEEDING DURING TEST
- Food type: Daily feed amounts of TetraMin®, approximately 1% of body weight, were supplied - Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Test temperature:
- 20 deg C
- Nominal and measured concentrations:
- 162, 126, 101 and 89 mg/l,
- Details on test conditions:
- Test vessel : 300-liter glass aquariums
Number of fish : Ten fish per 20 l test aquarium were exposed - Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 119 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: No mortalities were observed
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC0 observed after 96 h was 119 mg/l .No mortalities were observed.
- Executive summary:
Short term toxicity of test material was evaluated on Brachydanio rerio for 96 hr under semistatic condition according to Directive 92/69/EEC, C.1 . The test substance was added to the synthetic fresh water to provide a concentration of 1 g/l, and was stirred for 18 hours. Then the solution was filtered and the carbon content was determined. A single test concentration of 119 mg/l was measured for this study. Fish were held in dechlorinated circulating potable water in 200 -liter stoneware tanks or in 300-liter glass aquariums, at 20 deg C. Daily feed amounts of TetraMin®, approximately 1% of body weight, were supplied. The specimens were pre-conditioned (treatment: 3x per week with malachite green) and subjected to a 14-day quarantine. They were used in testing only after this treatment. Only specimens displaying normal behavior at the beginning of the test and free of obvious disease were used in the study. Fish were not fed during the test. The testing density was 10 specimens per test tank; 0.4 g each. Ten fish per 20 l test aquarium were exposed for 96 hrs to a test substance concentration of 0 or 119 mg/l. LC0 observed after 96 h was 119 mg/l .No mortalities were observed.
Reference
Description of key information
Short-term toxicity to fish:
Short term toxicity of test material was evaluated on Brachydanio rerio for 96 hr under semistatic condition according to Directive 92/69/EEC, C.1 . The test substance was added to the synthetic fresh water to provide a concentration of 1 g/l, and was stirred for 18 hours. Then the solution was filtered and the carbon content was determined. A single test concentration of 119 mg/l was measured for this study. Fish were held in dechlorinated circulating potable water in 200 -liter stoneware tanks or in 300-liter glass aquariums, at 20 deg C. Daily feed amounts of TetraMin®, approximately 1% of body weight, were supplied. The specimens were pre-conditioned (treatment: 3x per week with malachite green) and subjected to a 14-day quarantine. They were used in testing only after this treatment. Only specimens displaying normal behavior at the beginning of the test and free of obvious disease were used in the study. Fish were not fed during the test. The testing density was 10 specimens per test tank; 0.4 g each. Ten fish per 20 l test aquarium were exposed for 96 hrs to a test substance concentration of 0 or 119 mg/l. LC0 observed after 96 h was 119 mg/l .No mortalities were observed.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 119 mg/L
Additional information
Short-term toxicity to fish:
The effect of test material on fish was observed based on the data for target chemical from secondary source as well as data for read across substances
For the target substance ,short term toxicity of test material was evaluated on Brachydanio rerio for 96 hr under semistatic condition according to Directive 92/69/EEC, C.1 . The test substance was added to the synthetic fresh water to provide a concentration of 1 g/l, and was stirred for 18 hours. Then the solution was filtered and the carbon content was determined. A single test concentration of 119 mg/l was measured for this study. Fish were held in dechlorinated circulating potable water in 200 -liter stoneware tanks or in 300-liter glass aquariums, at 20 deg C. Daily feed amounts of TetraMin®, approximately 1% of body weight, were supplied. The specimens were pre-conditioned (treatment: 3x per week with malachite green) and subjected to a 14-day quarantine. They were used in testing only after this treatment. Only specimens displaying normal behavior at the beginning of the test and free of obvious disease were used in the study. Fish were not fed during the test. The testing density was 10 specimens per test tank; 0.4 g each. Ten fish per 20 l test aquarium were exposed for 96 hrs to a test substance concentration of 0 or 119 mg/l. LC0 observed after 96 h was 119 mg/l .No mortalities were observed.
The above data was supported by data for structurally similar read across substance according to secondary source the Short term toxicity to fish Brachydanio rerio suggest the test was performed in semi-static condition for 96-hr exposure period and limit test following Directive 92/69EEC, C.1 (Huls AG, 1993a).During experiment the LC0 value for short term toxicity to fish for test material was determined to be 119 mg/l.
Based on the value, the test material was considered to be non-toxic to fish and can be considered to be not classified as per the CLP regulations.
The above data was further supported by data for functionally similar read across substance according to secondary source the Short term toxicity to fish Brachydanio rerio suggest the test was performed in semi-static condition for 96-hr exposure period and limit test following Directive 92/69/EEC, C.1 (Degussa-Huls AG, 1993c).During experiment the LC0 value for short term toxicity to fish for test material was determined to be 245 mg/l.
Based on the value, the test material was considered to be non-toxic to fish and can be considered to be not classified as per the CLP regulations.
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