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EC number: 210-940-5 | CAS number: 626-27-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- no
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- Buffer solutions:
- 0.05 M acetate buffer solution pH 4
- 0.05 M phosphate buffer solution pH 7
- 0.05 M borate buffer pH 9
Buffer solutions for calibration of pH meter and electrode:
- standard buffer solutions pH 4 (Art. 33543), pH 7 (Art. 33546), pH 9 (Art. 33548) - Details on test conditions:
- Preparation of the test solutions:
- Two sets of test solutions, buffered to pH values of 4, 7 and 9, each with a test substance concentration of approx. 20 mg/l, were prepared by adding a stock solution of the test substance in acetonitrile to the corresponding buffer solution
lncubation and sampling:
- aliquots of the test solutions were filled into autosampler vials which had been pre-rinsed with the test solutions and which were tightly closed with crimp caps
- incubated at 25 °C in an autosampler at room temperature (approx. 25 °C)
- the concentration of the sample analyzed immediately after preparation was taken as initial concentration
- the test solutions were analyzed after time intervals
- one vessel at each pH value was used exclusively for pH measurements
- the pH values of the test solutions were measured at the start of incubation and at several sampling times - Duration:
- 6 h
- pH:
- 4
- Temp.:
- 25
- Initial conc. measured:
- 17 mg/L
- Duration:
- 4 h
- pH:
- 7
- Temp.:
- 25
- Initial conc. measured:
- 17 mg/L
- Duration:
- 1 h
- pH:
- 9
- Temp.:
- 25
- Initial conc. measured:
- 9.5 mg/L
- Number of replicates:
- two replicates; In the above-cited initial concentration is an average value of two measurements
- Transformation products:
- yes
- No.:
- #1
- Details on hydrolysis and appearance of transformation product(s):
- Hexanoic acid (CAS 111-14-8) is the hydrolysis product. A material balance was established for heptanoic anhydride and heptanoic acid using the corresponding reference solutions.
- % Recovery:
- 4.9
- pH:
- 4
- Temp.:
- 25 °C
- Duration:
- 5.2 h
- % Recovery:
- 10
- pH:
- 4
- Temp.:
- 25 °C
- Duration:
- 4.7 h
- % Recovery:
- 26.6
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 2.4 h
- % Recovery:
- 9.9
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 3.8 h
- % Recovery:
- 0
- pH:
- 9
- Temp.:
- 25 °C
- Duration:
- 56 min
- % Recovery:
- 2.4
- pH:
- 9
- Temp.:
- 25 °C
- Duration:
- 56 min
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.374 h-1
- DT50:
- 1.9 h
- Remarks on result:
- other: 95% confidence intervals for half-life: 1.6 - 2.2 h
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.451 h-1
- DT50:
- 1.5 h
- Remarks on result:
- other: 95% confidence intervals for half-life: 1.4 - 1.8 h
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 3.656 h-1
- DT50:
- 11 min
- Remarks on result:
- other: no confidence interval can be given because of low number of data points
- Validity criteria fulfilled:
- yes
- Conclusions:
- Heptanoic anhydride is hydrolytically instable with half-lives at 25 °C of 1.9 h at pH 4, 1.5 h at pH 7 and 11 minutes at pH 9.
- Executive summary:
The rate of hydrolysis of heptanoic anhydride in aqueous solution buffered to pH values of 4, 7 and 9 was studied according to EU testing guideline C.7. The substance is hydrolytically instable with half-lives at 25 °C of 1.9 h at pH 4, 1.5 h at pH 7 and 11 minutes at pH 9. Therefore the hydrolysis is base-catalyzed. Heptanoic anhydride can be considered as hydrolytically instable in the pH range 2 -10, which is of relevance for biological systems.
Reference
Description of key information
Heptanoic anhydride is hydrolytically instable with half-lives at 25 °C of 1.9 h at pH 4, 1.5 h at pH 7 and 11 minutes at pH 9.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1.5 h
- at the temperature of:
- 25 °C
Additional information
The half-life of 1.5 h was measured at pH 7.
Heptanoic anhydride can be considered as hydrolytically instable in the pH range 2-10, which is of relevance for biological systems.
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