Registration Dossier
Registration Dossier
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EC number: 213-651-2 | CAS number: 998-40-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1965-04-09
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Unknown volume of test material was applied to the back and ears of rabbits. Application exposures were 1, 5, 15 minutes and 20h for the back and 20h for ears.
Observations after 24h and 8d. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Tributylphosphine
- EC Number:
- 213-651-2
- EC Name:
- Tributylphosphine
- Cas Number:
- 998-40-3
- Molecular formula:
- C12H27P
- IUPAC Name:
- tributylphosphane
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No information available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- No information available
- Duration of treatment / exposure:
- Back: 1, 5, 15 minutes and 20h
Ear: 20h - Observation period:
- 8 days
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Basis:
- animal:
- Remarks:
- all
- Time point:
- 7 d
- Reversibility:
- not reversible
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- Observations after 24h and 8 days : Skin is bleeding and brown + Necrosis + Desquamation for all time exposures.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive) based on GHS criteria
- Conclusions:
- When applied to the skin of rabbits, tributylphosphine results in necrosis and bleeding. The substance is corrosive.
- Executive summary:
Although this study lacks details for full reliability, the results show that application of the test item on rabbit skin results in browning of the skin and bleeding after a few minutes or 20h of exposure, respectively. After 8 days, the effects are not reversible. Therefore, tributylphosphine should be regarded as a Corrosive substance.
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