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EC number: 278-079-8 | CAS number: 75147-23-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27.04 - 28.06.1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- The objective of the study was to determine the acute median lethal dosage after a single oral administration to rats.
After acclimatization, the animals were deprived of food before admistration of the test sample. The animals were doses orally by a stomach tube and observed for 14 days in which clinical examination and body weight follow-up was done. At autopsy the gross pathology was evaluated. - GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,5-dimethylbicyclo[3.2.1]octan-8-one oxime
- EC Number:
- 278-079-8
- EC Name:
- 1,5-dimethylbicyclo[3.2.1]octan-8-one oxime
- Cas Number:
- 75147-23-8
- Molecular formula:
- C10H17NO
- IUPAC Name:
- N-[(8E)-1,5-dimethylbicyclo[3.2.1]octan-8-ylidene]hydroxylamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: BOR: WISW, SPF TNO
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Firma Winkelmann, Versuchstierzucht, 4791 Borchen 1, Gartenstraße 300
- Weight at study initiation: males: 179.0 - 194.6 g; females: 137.5 - 165.1 g
- Housing: collection caging; Makrolon type III/ max. 5 rats + Ssniff bedding
- Fasting period before study: 16 hours
- Diet: ad libitum; pellets
- Water: ad libitum; Makrolon drinking bottles, 300 ml
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/- 2
- Humidity (%): 45- 55
- Photoperiod (hrs dark / hrs light): 12 hours daily, from 7.00 a.m. - 19.00 p.m.
- lighting: flourescent light, 120 Lux
IN-LIFE DATES: 27.04.1982 - 17.05.1982
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Oleum arachidis
- Details on oral exposure:
- DOSAGE PREPARATION: 15 % (R.F. 50 %, 15 %) solution in Oleum arachidis. The pH-value of the liquid was 5,9.
APPLICATION: stomach tube
RANGE FINDING STUDY: 5 pairs of 2 female rats: 10.0, 5.0, 2.5, 1.0 and 0.5 g/kg bw. - Doses:
- 500, 750, 1000 and 1500 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Preparation of animals: animals were deprived of food for 16h
- Duration of observation period following administration: 14 days
- Clinical observation: a modified Irvin-Screening; ca.10 min , 30 min and 1 h , 3 h , 24 h , 48 h , 72 h , 7 and 14 days.
- Frequency of observations and weighing: day 0 and day 14
- Necropsy of survivors performed: yes - Statistics:
- - Randomization: lottery drawing
- Calculation of the oral LD50
Results and discussion
- Preliminary study:
- The range finding study showed that all treated animals of the dosages 10, 5 and 2.5 g/kg died within 24 h. At the dosage of 1 g/kg 1 animal died 24 h. At the dosage of 0,5 g/kg no mortality was observed.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 730 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: mean value males and females
- Mortality:
- During 24 h all 10 animals died at the dosage of 1.5 g/kg. At dose 1 g/kg 6 animals died within 24 h and altogether 9 animals of 10 treated within 3 days. At the dosage of 0.75 g/kg 1 animal died within 24 h and after 3 days 5 out of 10 treated animals. At the dosage of 0.5 g/kg 1 animal died within 48 h.
- Clinical signs:
- The substance induced an increase in restlessness, slight stereotypy and irritability, pointing to an excitation stage which was followed by partly complete apathia (similar to narcosis). Above the severe abnormal body posture, obvious disturbance of coordination, partly obvious reduced reflex excitability, slight decreased respiration rate and slight to obvious hyperemia was observed. The latter transformed after 3 h partly into a slight cyanosis. The symptoms described hold on in the animals dying in the same severe intensity until death. The surviving animals showed this in decreased intensity up to 48 h. Afterwards and during the remaining observation period the animals showed a normal disposition.
- Body weight:
- Body weight changes of the surviving animals after the observation period showed a normal weight gain.
- Gross pathology:
- The animals that died during the study showed at autopsy slight to obvious redness of the whole digestive systems. Nothing abnormal was found in the animals necropsied on day 14.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 was determined to be 790 mg/kg for male rats and 640 mg/kg for female rats. The mean LD50 was 730 mg/kg.
- Executive summary:
In the current study the acute oral toxicity was investigated after a single oral administration of the test item. Four groups of fasted male and female rats of the WISW-strain rats were dosed by a stomach tube. Any signs of reaction and mortalities were recorded during the 14-days observation period, animals that died and those that were killed at the end of the study were subjected to necropsy.
The doses tested were 0.5, 0.75, 1.0 and 1.5 g/kg
The test item affected the awareness and coordination. Moreover, the animals showed an abnormal body posture and reduced reflex excitability. Also, a decrease in respiration rate was observed, as well as hyperemia and cyanosis.
The post-dosing weight gains of the surviving animals were not essentially different after 2 weeks.
The animals that died during the study showed a slight to obvious redness of the whole digestive system. No abnormalities were found in the animals necropsied at day 14.
The mortality rates were:
Dose (mg/kg)
Mortality rate
1500
10/10
1000
9/10
750
5/10
500
1/10
The acute oral LD50 was determined to be 790 mg/kg for male rats and 640 mg/kg for female rats. The mean LD50 was 730 mg/kg.
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