3,4-diethoxyphenethylamine

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Report date:

2016

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

not specified

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

3,4-diethoxyphenethylamine

EC Number:

262-752-8

EC Name:

3,4-diethoxyphenethylamine

Cas Number:

61381-04-2

Molecular formula:

C12H19NO2

IUPAC Name:

3,4-diethoxyphenethylamine

Test material form:

liquid

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

yes

Remarks:

water

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

The Daphnia introduced in the test were taken from ibacon's in-house laboratory culture.

Study design

Test type:

static

Total exposure duration:

48 h

Test conditions

Hardness:

2.5 mmol/L (= 250 mg/L) as CaCO3

Test temperature:

20 °C at test start;
19 °C at test end

pH:

8.0 to 8.1 at test start;
7.9 at test end

Dissolved oxygen:

8.6 to 9.0 mg/L at test start;
7.9 to 8.3 mg/L at test end

Nominal and measured concentrations:

100, 50, 25, 12.5, and 6.25 mg test item/L and a control

Results and discussion

Effect concentrations

Effect concentrations 1

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Basis for effect:

mobility

Effect concentrations 2

Key result

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

ca. 50 mg/L

Nominal / measured:

nominal

Basis for effect:

mobility

Details on results:

The toxic effect of the test item Diethoxy Amine (CAS 61381-04-2) to Daphnia magna was assessed in a static dose-response test. The 48-hour NOEC was determined to be 50 mg test item/L. The 48-hour
LOEC was determined to be 100 mg test item/L and the 48-hour EC50 value was determined to be > 100 mg test item/L.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The toxic effect of the test item Diethoxy Amine (CAS 61381-04-2) to Daphnia magna was assessed in a static dose-response test. The 48-hour NOEC was determined to be 50 mg test item/L. The 48-hour EC50
value was determined to be > 100 mg test item/L.