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EC number: 253-675-0 | CAS number: 37811-72-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Data on the aquatic toxicity ofisobutyl laurate (CAS 37811-72-6)
are not available.
In accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006,
read-across to the structurally related substances Isopropyl myristate
(CAS 110-27-0) and Fatty acids, C16-18 and C18-unsatd., iso-Bu esters
(CAS 84988-79-4) was conducted to fulfil the standard information
requirements. In accordance with Article 13 (1) of Regulation (EC) No
1907/2006, "information on intrinsic properties of substances may be
generated by means other than tests, provided that the conditions set
out in Annex XI are met.” In particular for aquatic toxicity,
information shall be generated whenever possible by means other than
vertebrate animal tests, which includes the use of information from
structurally related substances (grouping or read-across). According to
Annex XI, Item 1.5, of Regulation (EC) No 1907/2006 substances can be
considered to be similar if their physicochemical, toxicological and
ecotoxicological properties are likely to be similar or follow a regular
pattern as a result of structural similarity.
Isobutyl laurate (CAS 37811-72-6) is a branched C4 alcohol esterified with a linear C12 fatty acid chain. The source substance Isopropyl myristate (CAS 110-27-0) is a branched alcohol (C3) esterified with alinear fatty acid chain (C12). Both substances are mono constituents. Whereas Fatty acids, C16-18 and C18-unsatd., iso-Bu esters (CAS 84988-79-4) is an UVCB substance comprising linear saturated and unsatured fatty acid chains (C14 – C18) esterified with a linear C4 alcohole. The read across substances cover the fatty acid chain length of the source substance as well as the characteristics of the alcohole moiety of the source substance.
Target and source substances are characterised by a low water
solubility, low vapour pressure and comparable log Koc values. Thus, the
substances are expected to have a similar environmental fate and
ecotoxicity profile.
The available short-term and long-term studies indicate that the source
substances are not acutely toxic to aquatic organisms up to the limit of
water solubility.
In accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5, grouping and read-across the target substance isobutyl laurate (CAS 37811-72-6) is considered not harmful to aquatic organisms based on the results of the available read across studies conducted with fish, aquatic invertebrates and algae and long-term results on toxicity to aquatic invertebrates.
Experimental data on the acute toxicity of the read-across substance Isopropyl myristate (CAS 110-27-0) are available for fish, aquatic invertebrates and algae. No toxicity of the substance was determined up to the limit of water solubility. Comparable results were determined for the second read across substance Fatty acids, C16-18 and C18-unsatd., iso-Bu esters (CAS 84988-79-4). The available acute toxicity test on fish, aquatic invertebrates and algae determined LC50 and EL50 values > 100 mg/L respectively.
Data on chronic toxicity are available for Isopropyl myristate (CAS 110-27-0). The long-term toxicity of the substance to Daphnia magna was tested. An effect on survival and reproduction rate of the daphnids was not observed up to the limit of water solubility (NOELR (21 d) ≥ 100 mg/L). Similar results were recorded in a study on the long-term toxicity of Fatty acids, C16-18 and C18-unsatd., iso-Bu esters (CAS 84988-79-4) to Daphnia magna. No mortality and detrimental effects on the reproduction were determined for the substance (NOELR (21 d) ≥ 100 mg/L).
Data on the toxicity to microorganisms are available for Isopropyl myristate (CAS 110-27-0). Adverse effects of the substances to microorganisms were not observed.
The available acute toxicity data of the read-across substances demonstrate that toxic effects of the target substance isobutyl laurate (CAS 37811-72-6) up to the limit of water solubility are not likely. Consequently, additional acute and chronic testing is omitted. Based on the result from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be concluded that isobutyl laurate (CAS 37811-72-6)will not show toxic effects on freshwater organisms up to the limit of water solubility (WS < 3 µg/L at 20 °C).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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