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EC number: 638-801-8 | CAS number: 949465-81-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26/07/2010-18/08/2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Regulation (EC) No.440/2008, L142, Annex part B, 30 May 2008
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- ethyl 3-{5-[(3-chloro-2-fluorophenyl)methyl]-2,4-dimethoxyphenyl}-3-oxopropanoate
- EC Number:
- 638-801-8
- Cas Number:
- 949465-81-0
- Molecular formula:
- C20H20ClFO5
- IUPAC Name:
- ethyl 3-{5-[(3-chloro-2-fluorophenyl)methyl]-2,4-dimethoxyphenyl}-3-oxopropanoate
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- The animals were derived from a controlled full-barrier maintained breeding system (SPF). According to Art.9.2, No.7 of the German Act on Animal Welfare the animals were bred for experimental purposes.
TEST ANIMALS
- Source: Charles River, 97633 Sulzfeld, Germany
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: 8-9 weeks old
- Weight at study initiation: Animals N.1-3, step 1: 163-167 g; Animals N.4-6, step 2: 147-159 g
- Housing: Full barrier in an air-conditioned room
- Diet (e.g. ad libitum): free access
- Water (e.g. ad libitum): free access
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/-3°C
- Humidity (%): 55 +/- 10%
- Air changes (per hr): 10 x/ hour
- Photoperiod (hrs dark / hrs light): artificial light, 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- cotton seed oil
- Details on oral exposure:
- The test item was administered at a single dose by gavage using a feeding tube.
- Doses:
- 2000 mg/kg bw.
- No. of animals per sex per dose:
- 3 per step
- Control animals:
- yes
- Details on study design:
- All animals were observed for 14 days after dosing for general clinical signs, morbidity and mortality.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No compound-related mortality was recorded for any animal of step 1 or 2.
- Clinical signs:
- other: No signs of toxicity.
- Gross pathology:
- The test item showed no acute oral toxicity characteristics after a single dose administration.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the present study, single oral application of the test item GS-9207 to rats at a dose of 2000 mg/kg bw was associated with no signs of toxicity nor mortality.
The median lethal dose of GS-9207 after single oral administration to female rats, observed over a period of 14 days is: LD50 cut off (rat): unclassified.
In conformity with the criteria given in Annex VI to Commission Directive 2001/59/EC the test item GS-9207 has no obligatory labelling requirement for toxicity.
According to Annex I of regulation (EC) 1272/2008 the test item GS-9207 was unclassified.
According to OECD-GHS the test item GS-9207 has no obligatory labelling requirement for toxicity.
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