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Diss Factsheets
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EC number: 205-793-9 | CAS number: 151-56-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No GLP compliance. It does not follow any guideline, as it is an observation related to exposure to chemicals.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
- Type of study / information:
- This is a report on the observation of chromosome damage in chemical workers.
- Endpoint addressed:
- genetic toxicity
- Principles of method if other than guideline:
- The chromosome analysis was carried out with lymphocites tested according to the method of Moorhead slightly modified.
- GLP compliance:
- no
Test material
- Reference substance name:
- Aziridine
- EC Number:
- 205-793-9
- EC Name:
- Aziridine
- Cas Number:
- 151-56-4
- Molecular formula:
- C2H5N
- IUPAC Name:
- aziridine
Constituent 1
Method
- Ethical approval:
- not applicable
- Exposure assessment:
- measured
- Details on exposure:
- Observations were done in chromosomes of workers exposed to ethyleneimine from some months to 23 years. Since 1966, regular analysis of the air always revealed a value of less than 0.5 ppm ethylenimine.
Results and discussion
- Results:
- Healthy control subjects presented a certain percentage of spontaneous chromosome aberrations.
The percentage of chromosome aberration for workers exposed to ethyleneimine was 1-4%, not higher than the spontaneous chromosome aberrations.
Any other information on results incl. tables
No more available data on the results.
Applicant's summary and conclusion
- Conclusions:
- The percentage of chromosome aberration for workers exposed to ethyleneimine was 1-4%, not higher than the spontaneous chromosome aberrations.
- Executive summary:
This paper refers to the chromosome study carried out in chemical workers, exposed to different substances (ethyleneimine among them).
The investigations were recorded on chromosome damage of workers exposed to ethyleneimine from some months to 23 years. Since 1966, regular analysis of the air always revealed a value of less than 0.5 ppm ethylenimine. Healthy control subjects presented a certain percentage of spontaneous chromosome aberrations.
The percentage of chromosome aberration for workers exposed to ethyleneimine was 1-4%, not higher than the spontaneous chromosome aberrations.
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