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EC number: 288-657-1 | CAS number: 85857-16-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 2001
- Qualifier:
- according to guideline
- Guideline:
- other: EC 440/2008
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Trimethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane
- EC Number:
- 288-657-1
- EC Name:
- Trimethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane
- Cas Number:
- 85857-16-5
- Molecular formula:
- C11H13F13O3Si
- IUPAC Name:
- trimethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane
- Reference substance name:
- [2-(Perfluorohexyl)ethyl]trimethoxysilane
- IUPAC Name:
- [2-(Perfluorohexyl)ethyl]trimethoxysilane
- Test material form:
- other: liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, 94633 Sulzfield, Germany
- Age at study initiation: 9-11 weeks
- Weight at study initiation: animals 1-3: 155-166 g; animals 4-6: 139-142 g
- Fasting period before study: 16-19 hours prior to administration
- Housing: Groups in IVC cages, type III H, polysulphone cages on Altromin saw fibre bedding (lot no. 02102140831)
- Diet: Altromin 1324 maintenance diet for rats and mice (lot no. 1239) ad libitum
- Water: tap water ad libitum, sulphur acidified to a pH value of approximately 2.8 (drinking water, municipal residue control, microbiological controls at regular intervals)
- Acclimation period: at least 5 days under laboratory conditions
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3°C
- Humidity (%): 55 ± 10%
- Air changes (per hr): 10 x / hour
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 per step
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighed on day 1 (prior to administration), day 8 and day 15; clinical examination made several times on the day of dosing (at least once during the first 30 minutes, and with special attention given during the first 4 hours post-dose). Thereafter, the animals were observed once daily until the end of the observation period.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, other: morbidity, mortality, changes in the skin, fur, eyes and mucous membranes, changes in respiratory system, circulatory system, autonomic system and CNS. Particular attention directed to observation of tremor, convulsions, salivation, diarrhoea, lethargy, sleep and coma. - Statistics:
- None described in report.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortalities.
- Clinical signs:
- No specific signs.
- Body weight:
- None of the animals showed weight loss during the observation period, and the body weight gains were within the normal range of variation for the strain.
- Gross pathology:
- No specific gross pathological changes were recorded for any animal.
Any other information on results incl. tables
Acute oral toxicity: absolute body weights and body weight gain
Step |
Animal No. |
Starting Dose (mg/kg bw) |
Body weight (g) |
Body weight in comparison to day 1 (%) |
||
Day 1 |
Day 8 |
Day 15 |
||||
1 |
1 |
2000 |
166 |
196 |
193 |
16 |
2 |
155 |
171 |
177 |
14 |
||
3 |
166 |
190 |
198 |
19 |
||
2 |
4 |
2000 |
139 |
154 |
170 |
22 |
5 |
142 |
158 |
172 |
21 |
||
6 |
141 |
162 |
173 |
23 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- [2-(perfluorohexyl)ethyl]trimethoxysilane has been tested in an acute oral toxicity study conducted according to OECD 423 and in compliance with GLP. The undiluted test substance was administered by gavage to two groups, each of 3 female rats. The rats were dosed at 2000 mg/kg bw. There were no deaths and no signs of systemic reaction to treatment. All animals achieved satisfactory bodyweight gains throughout the study. The LD₅₀ was determined to be >2000 mg/kg bw.
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